1. Epoxygenase eicosanoids: Synthesis of tetrahydrofuran-diol metabolites and their vasoactivity
- Author
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L. Manmohan Reddy, Xiu Yu Yi, John R. Falck, Kihwan Byun, and William B. Campbell
- Subjects
Epoxygenase ,Stereochemistry ,Chemistry, Pharmaceutical ,Vasodilator Agents ,Clinical Biochemistry ,Diol ,Molecular Conformation ,Pharmaceutical Science ,Vasodilation ,Stereoisomerism ,Biochemistry ,Chemical synthesis ,Article ,chemistry.chemical_compound ,Drug Discovery ,Animals ,Furans ,Molecular Biology ,Unsaturated fatty acid ,Tetrahydrofuran ,Dose-Response Relationship, Drug ,biology ,Chemistry ,Organic Chemistry ,Arteries ,Models, Chemical ,Eicosanoid ,Drug Design ,Oxygenases ,biology.protein ,Eicosanoids ,Molecular Medicine ,Cattle - Abstract
Eight members of a recently identified family of tetrahydrofuran-diols (THFDs), originating from epoxyeicosatrienoic acids (EETs), were prepared stereospecifically from D-(+)-glucose. The THFDs potently induced relaxation of pre-contracted bovine arteries.
- Published
- 2007
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