Search

Your search keyword '"Ha, Tran Thu"' showing total 4 results
Start Over Author "Ha, Tran Thu" Journal bioorganic & medicinal chemistry letters
4 results on '"Ha, Tran Thu"'

3. C29 sterols with a cyclopropane ring at C-25 and 26 from the Vietnamese marine sponge Ianthella sp. and their anticancer properties

Author

Tung, Nguyen Huu, primary, Minh, Chau Van, additional, Ha, Tran Thu, additional, Kiem, Phan Van, additional, Huong, Hoang Thanh, additional, Dat, Nguyen Tien, additional, Nhiem, Nguyen Xuan, additional, Tai, Bui Huu, additional, Hyun, Jae-Hee, additional, Kang, Hee-Kyoung, additional, and Kim, Young Ho, additional

Published
2009
Full Text
View/download PDF

4. C29 sterols with a cyclopropane ring at C-25 and 26 from the Vietnamese marine sponge Ianthella sp. and their anticancer properties

Author

Tung, Nguyen Huu, Minh, Chau Van, Ha, Tran Thu, Kiem, Phan Van, Huong, Hoang Thanh, Dat, Nguyen Tien, Nhiem, Nguyen Xuan, Tai, Bui Huu, Hyun, Jae-Hee, Kang, Hee-Kyoung, and Kim, Young Ho

Subjects
*STEROLS, *CYCLOPROPANE, *SPONGES (Invertebrates), *ANTINEOPLASTIC agents, *APOPTOSIS, *CELL-mediated cytotoxicity, *LEUKEMIA treatment, *THERAPEUTICS
Abstract

Abstract: Two new C29 sterols with a cyclopropane ring at C-25 and C-26, petrosterol-3,6-dione (1) and 5α,6α-epoxy-petrosterol (2), along with petrosterol (3), were isolated from the Vietnamese marine sponge Ianthella sp. The structures of the new compounds were elucidated by comprehensive spectroscopic analyses. Compounds 1−3 showed cytotoxic activities on A549, HL-60, MCF-7, SK-OV-3, and U937 cancer cell lines with IC50 in the range of 8.4–22.6μM, whereas compounds 1−3 exhibited only weak cytotoxic activities on HT-29 cell. After HL-60 cells were treated with the compounds, several apoptosis events like chromatin condensation and the increase of the population of sub-G1 hypodiploid cells were observed. These data supported that the compounds might have potential for leukemia treatment. [Copyright &y& Elsevier]

Published
2009
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results