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1. Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues

Author

El Fangour, Siham, Balas, Laurence, Rossi, Jean-Claude, Fedenyuk, Andrey, Gretskaya, Natalia, Bobrov, Mikhail, Bezuglov, Vladimir, Hillard, Cecilia J., and Durand, Thierry

Subjects
*CANNABINOIDS, *ESTERS
Abstract

Three new endocannabinoid analogues in which amide moiety was replaced either by oxomethylene group or ester moiety with simultaneous substitution of both α-hydrogens with methyl groups were synthesized and their abilities to interact with CB1-receptor and FAAH were investigated. [Copyright &y& Elsevier]

Published
2003
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