1. Fused thiophene derivatives as MEK inhibitors
- Author
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Laing, Victoria E., Brookings, Daniel C., Carbery, Rachel J., Simorte, Jose Gascon, Hutchings, Martin C., Langham, Barry J., Lowe, Martin A., Allen, Rodger A., Fetterman, Joanne R., Turner, James, Meier, Christoph, Kennedy, Jeff, and Merriman, Mark
- Subjects
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THIOPHENES , *MITOGEN-activated protein kinases , *ENZYME inhibitors , *COLON cancer , *ANTINEOPLASTIC agents , *DRUG development - Abstract
Abstract: A number of novel fused thiophene derivatives have been prepared and identified as potent inhibitors of MEK. The SAR data of selected examples and the in vivo profiling of compound 13h demonstrates the functional activity of this class of compounds in HT-29 PK/PD models. [Copyright &y& Elsevier]
- Published
- 2012
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