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Your search keyword '"Edwards, Martin"' showing total 6 results
Start Over Author "Edwards, Martin" Publication Year Range Last 50 years Journal bioorganic & medicinal chemistry letters
6 results on '"Edwards, Martin"'

1. N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1: Strategies to eliminate reactive metabolites

Author

Nair, Sajiv K., Matthews, Jean J., Cripps, Stephan J., Cheng, Hengmiao, Hoffman, Jacqui E., Smith, Christopher, Kupchinsky, Stanley, Siu, Michael, Taylor, Wendy D., Wang, Yong, Johnson, Theodore O., Dress, Klaus R., Edwards, Martin P., Zhou, Sue, Hosea, Natilie A., LaPaglia, Amy, Kang, Ping, Castro, Arturo, Ermolieff, Jacques, Fanjul, Andrea, Vogel, Jennifer E., Rejto, Paul, and Dalvie, Deepak

Published
2013
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2. The development and SAR of pyrrolidine carboxamide 11β-HSD1 inhibitors

Author

Cheng, Hengmiao, Hoffman, Jacqui, Le, Phuong, Nair, Sajiv K., Cripps, Stephan, Matthews, Jean, Smith, Christopher, Yang, Michele, Kupchinsky, Stan, Dress, Klaus, Edwards, Martin, Cole, Bridget, Walters, Evan, Loh, Christine, Ermolieff, Jacques, Fanjul, Andrea, Bhat, Ganesh B., Herrera, Jocelyn, Pauly, Tom, Hosea, Natilie, Paderes, Genevieve, and Rejto, Paul

Published
2010
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6. Rapid assessment of a novel series of selective CB2 agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis

Author

Ryckmans, Thomas, Edwards, Martin P., Horne, Val A., Correia, Ana Monica, Owen, Dafydd R., Thompson, Lisa R., Tran, Isabelle, Tutt, Michelle F., and Young, Tim

Subjects
*SULFONAMIDES, *DRUG derivatives, *DRUG design, *CHEMICAL templates, *CHEMICAL libraries, *DRUG metabolism
Abstract

Abstract: A series of libraries were designed using the 1-(cyclopropylmethyl)-2-alkyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-5-ium templates 2a–b, and Sulfonamide derivatives 11a–n proved to be potent agonists of the CB2 receptor. Analysis of the Lipophilic Efficiency (LipE) of potent compounds provided new insight for the design of potent, metabolically stable CB2 agonists. [Copyright &y& Elsevier]

Published
2009
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