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Start Over Author "Hernández, Juan C." Topic glucosides Journal bioorganic & medicinal chemistry
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1. Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco

Author

Hernández, Juan C., León, Francisco, Quintana, José, Estévez, Francisco, and Bermejo, Jaime

Subjects
*DRACAENA, *ASPARAGACEAE, *SAPONINS, *GLUCOSIDES
Abstract

This paper reports on the cytotoxic effect induced by a new natural steroidal saponin, icogenin, on the myeloid leukemia cell line HL-60. Icogenin was found to be a cytotoxic compound IC50 2.6 ± 0.9 μM at 72 h, with growth inhibition caused by the induction of apoptosis, as determined by microscopy of nuclear changes and the fragmentation of poly(ADP-ribose) polymerase-1. [Copyright &y& Elsevier]

Published
2004
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