1. Synthesis of novel spirostanic saponins and their cytotoxic activity
- Author
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Hernández, Juan C., León, Francisco, Brouard, Ignacio, Torres, Fernando, Rubio, Sara, Quintana, José, Estévez, Francisco, and Bermejo, Jaime
- Subjects
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CANCER , *APOPTOSIS , *CELL death , *NEUROENDOCRINE tumors - Abstract
Abstract: This study was carried out to assess the cytotoxicity of several new synthetic steroidal saponins against the human myeloid leukemia cell lines (HL-60 and U937) and against human melanoma cells (SK-MEL-1). Several diosgenyl glycosides analyzed showed strong cell growth inhibition which was associated with alterations in cell cycle progression and induction of apoptosis. Studies of cytochrome c release and caspase-9 activation suggest a main role of the intrinsic pathway of apoptosis in the mechanism of cytotoxicity caused by this kind of compounds. [Copyright &y& Elsevier]
- Published
- 2008
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