1. Identification of the Marine Alkaloid Lepadin A as Potential Inducer of Immunogenic Cell Death.
- Author
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Nuzzo, Genoveffa, Gallo, Carmela, Crocetta, Fabio, Romano, Lucia, Barra, Giusi, Senese, Giuseppina, dell'Isola, Mario, Carbone, Dalila, Tanduo, Valentina, Albiani, Federica, Villani, Guido, d'Ippolito, Giuliana, Manzo, Emiliano, and Fontana, Angelo
- Subjects
T helper cells ,CELL death ,MARINE natural products ,SYNTHETIC products ,NATURAL products ,ISOQUINOLINE alkaloids ,ALKALOIDS - Abstract
Natural products and their synthetic analogs and derivatives are a traditional source of bioactive molecules with potential development as drug candidates. In this context, Marine Natural Products (MNPs) represent a rich reservoir of diverse molecular skeletons with potential pharmacological activity that, so far, has been mostly explored in cancer and infectious diseases. Starting from the development of a novel bioassay-guided screening platform for immunomodulatory compounds from an in-house MNPs library, we report the identification of the alkaloid lepadin A as a new model compound for immune-based anticancer activity with characteristics that suggest a possible mechanism as Immunogenic Cell Death inducer. The work describes the molecular-based bioprospecting in the Gulf of Naples together with the bioassay-guided fractionation, the chemical characterization of the alkaloid, and the biological activity in mouse dendritic cells (D1). [ABSTRACT FROM AUTHOR]
- Published
- 2022
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