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Cosmeceutical peptides have become an important topic in recent decades in both academic and industrial fields. Many natural or synthetic peptides with different biological functions including anti-ageing, anti-oxidation, anti-infection and anti-pigmentation have been developed and commercialized. Current cosmeceutical peptides have already satisfied most market demand, remaining: "cargos carrying skin penetrating peptide with high safety" still an un-met need. To this aim, a cell-penetrating peptide, CPP AIF , which efficiently transported cargos into epithelial cells was exanimated. CPP AIF was evaluated with cell model and 3D skin model following OECD guidelines without using animal models. As a highly stable peptide, CPP AIF neither irritated nor sensitized skin, also did not disrupt skin barrier. In addition, such high safety peptide had anti-inflammation activity without allergic effect. Moreover, cargo carrying activity of CPP AIF was assayed using HaCaT cell model and rapid CPP AIF penetration was observed within 30 min. Finally, CPP AIF possessed transepidermal activity in water in oil formulation without disruption of skin barrier. All evidences indicated that CPP AIF was an ideal choice for skin penetrating and its anti-inflammatory activity could improve skin condition, which made CPP AIF suitable and attractive for novel cosmeceutical product development., Competing Interests: The authors declare no conflict of interest.