1. Paternal High-Protein Diet Programs Offspring Insulin Sensitivity in a Sex-Specific Manner
- Author
-
Junjun Liu, Maria G. Stathopoulou, Stefania Tolu, Gaëlle Pommier, Bernard Portha, Pengfei Gong, Danielle Bailbe, Jamileh Movassat, Valérie Grandjean, Lola Bianchi, Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Shandong University, Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), and ORANGE, Colette
- Subjects
0301 basic medicine ,Male ,insulin secretion ,[SDV]Life Sciences [q-bio] ,High-protein diet ,medicine.disease_cause ,Biochemistry ,ENERGY ,0302 clinical medicine ,Insulin-Secreting Cells ,Glucose homeostasis ,Sex Characteristics ,INDUCED OBESITY ,GLUCOSE-METABOLISM ,paternal programming ,QR1-502 ,[SDV] Life Sciences [q-bio] ,PREGNANCY ,medicine.anatomical_structure ,POSTMENOPAUSAL WOMEN ,Paternal Exposure ,Diet, High-Protein ,Female ,Pancreas ,BETA-CELL MASS ,HIGH-FAT-DIET ,endocrine pancreas ,DIABETES RISK ,EXPRESSION ,medicine.medical_specialty ,sperm small non-coding RNAs ,Offspring ,030209 endocrinology & metabolism ,Microbiology ,DEVELOPMENTAL ORIGINS ,Article ,03 medical and health sciences ,In vivo ,Internal medicine ,high-protein diet ,medicine ,Endocrine system ,glucose homeostasis ,insulin sensitivity ,Animals ,Rats, Wistar ,Insulin secretion ,Molecular Biology ,business.industry ,Body Weight ,Insulin sensitivity ,Rats ,030104 developmental biology ,Endocrinology ,Case-Control Studies ,Insulin Resistance ,business - Abstract
The impact of maternal nutrition on offspring is well documented. However, the implication of pre-conceptional paternal nutrition on the metabolic health of the progeny remains underexplored. Here, we investigated the impact of paternal high-protein diet (HPD, 43.2% protein) consumption on the endocrine pancreas and the metabolic phenotype of offspring. Male Wistar rats were given HPD or standard diet (SD, 18.9% protein) for two months. The progenies (F1) were studied at fetal stage and in adulthood. Body weight, glycemia, glucose tolerance (GT), glucose-induced insulin secretion in vivo (GIIS) and whole-body insulin sensitivity were assessed in male and female F1 offspring. Insulin sensitivity, GT and GIIS were similar between F1 females from HPD (HPD/F1) and SD fathers (SD/F1). Conversely, male HPD/F1 exhibited increased insulin sensitivity (p <, 0.05) and decreased GIIS (p <, 0.05) compared to male SD/F1. The improvement of insulin sensitivity in HPD/F1 was sustained even after 2 months of high-fat feeding. In male HPD/F1, the β cell mass was preserved and the β cell plasticity, following metabolic challenge, was enhanced compared to SD/F1. In conclusion, we provide the first evidence of a sex-specific impact of paternal HPD on the insulin sensitivity and GIIS of their descendants, demonstrating that changes in paternal nutrition alter the metabolic status of their progeny in adulthood.
- Published
- 2021
- Full Text
- View/download PDF