1. Evaluation of the miRNA profiling and effectiveness of the propolis on B-cell acute lymphoblastic leukemia cell line
- Author
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Sunde Yilmaz Susluer, Ozgur Cogulu, Cigir Biray Avci, Asude Durmaz, Emin Karaca, Hüsniye Kayalar, Ugur Yilmaz, Burak Durmaz, Cumhur Gündüz, Ayca Aykut, and Bakiye Goker Bagca
- Subjects
0301 basic medicine ,Carcinogenesis ,Apoptosis ,Pharmacology ,Biology ,medicine.disease_cause ,Propolis ,03 medical and health sciences ,Inhibitory Concentration 50 ,0302 clinical medicine ,Cell Line, Tumor ,microRNA ,medicine ,Leukemia, B-Cell ,Humans ,Epigenetics ,Gene Expression Regulation, Leukemic ,Gene Expression Profiling ,General Medicine ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,medicine.disease ,Gene expression profiling ,Leukemia ,MicroRNAs ,030104 developmental biology ,Cell culture ,030220 oncology & carcinogenesis - Abstract
Acute lymphoblastic leukemia (ALL) is one of the most frequent causes of death from cancer. Since the discovery of chemotherapeutic agents, ALL has become a model for improvement of survival. In parallel to this, serious side effects were observed and new natural therapeutic options has been discussed. One of these substances is called propolis which is a resinous substance gathered by honeybees. In the molecular era, miRNAs have been shown to play crucial roles in the development of many clinical conditions. The aim of this study is to evaluate the effect of Aydin propolis on 81 human miRNA activity in CCRF-SB leukemia cell line. Apoptotic effects of propolis on cell lines were also evaluated and apoptosis were found to be induced 1.5 fold in B-cell leukemia cells. The expression of 63 miRNAs (46 miRNAs were downregulated, 19 miRNAs were upregulated) in propolis treated leukemia cells have changed significantly (p
- Published
- 2016