1. Acute and sub-acute toxicity study of hydro-alcoholic leaves extract of Reinwardtia indica in rats
- Author
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Prabhat Upadhyay, Sunil Kumar Mishra, and Rashmi Shukla
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Subacute toxicity ,Physiology ,Histopathology ,RM1-950 ,Reinwardtia ,Body weight ,Eating ,03 medical and health sciences ,0302 clinical medicine ,Toxicity Tests, Acute ,Animals ,Medicine ,Hematological test ,Pharmacology ,Dose-Response Relationship, Drug ,Ethanol ,biology ,Plant Extracts ,business.industry ,Body Weight ,Water ,General Medicine ,Linaceae ,biology.organism_classification ,Acute toxicity ,Rats ,Plant Leaves ,Toxicity Tests, Subacute ,030104 developmental biology ,030220 oncology & carcinogenesis ,Toxicity ,Reinwardtia indica ,Female ,Therapeutics. Pharmacology ,business - Abstract
The present study was to assess the toxicity of hydro alcoholic leaves extract of Reinwardtia indica in Charles foster rats through an acute and sub-acute study. In the acute study, rats were treated orally with single dose and for sub-acute study different doses were given orally for 28 consecutive days. At the dose of 2000 mg/kg satellite group was also used for 6 weeks as per OECD guidelines-407. General behavioral parameters were assessed in acute toxicity and found no mortality or exterior signs of toxicity. While in the sub-acute study; biochemical, hematological and histopathology along with the body weight, food, and water consumptions parameters were screened in the animals after 14 & 28 days. The study reveals the insignificant (P
- Published
- 2019