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Your search keyword '"Gaurav Raj Dwivedi"' showing total 2 results
Start Over Author "Gaurav Raj Dwivedi" Journal biomedicine & pharmacotherapy
2 results on '"Gaurav Raj Dwivedi"'

1. Drug resistance reversal potential of multifunctional thieno[3,2-c]pyran via potentiation of antibiotics in MDR P. aeruginosa

Author

Gaurav Raj Dwivedi, Reeta Rai, Ramendra Pratap, Khusbu Singh, Sanghamitra Pati, Satya Narayan Sahu, Rajni Kant, Mahendra P. Darokar, and Dharmendra K. Yadav

Subjects
Thieno[3, 2-c]pyran-2-ones, Drug resistance reversal, Synthetic compounds, Efflux pump inhibition, Biofilm synthesis, Therapeutics. Pharmacology, RM1-950
Abstract

We explored the antibacterial potential (alone and combination) against multidrug resistant (MDR) Pseudomonas aeruginosa isolates KG-P2 using synthesized thieno[3,2-c]pyran-2-ones in combination with different antibiotics. Out of 14 compounds, two compounds (3g and 3l) abridged the MIC of tetracycline (TET) by 16 folds. Compounds was killing the KG-P2 cells, in time dependent manner, lengthened post-antibiotic effect (PAE) of TET and found decreased the mutant prevention concentration (MPC) of TET. In ethidium bromide efflux experiment, two compounds repressed the drug transporter (efflux pumps) which is further supported by molecular docking of these compounds with efflux complex MexAB-OprM. In another study, these compounds inhibited the synthesis of biofilm.

Published
2021
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2. Drug resistance reversal potential of multifunctional thieno[3,2-c]pyran via potentiation of antibiotics in MDR P. aeruginosa

Author

Ramendra Pratap, Sanghamitra Pati, Reeta Rai, Gaurav Raj Dwivedi, Rajni Kant, Khusbu Singh, Dharmendra Kumar Yadav, Satya Narayan Sahu, and Mahendra P. Darokar

Subjects
Time Factors, Tetracycline, medicine.drug_class, Antibiotics, Drug resistance reversal, Microbial Sensitivity Tests, Drug resistance, RM1-950, medicine.disease_cause, Structure-Activity Relationship, chemistry.chemical_compound, Drug Resistance, Multiple, Bacterial, medicine, Efflux pump inhibition, Pharmacology, Chemistry, Pseudomonas aeruginosa, Biofilm, Drug Synergism, General Medicine, biochemical phenomena, metabolism, and nutrition, 2-c]pyran-2-ones, Molecular biology, Anti-Bacterial Agents, Molecular Docking Simulation, Multiple drug resistance, Pyrones, Biofilms, Biofilm synthesis, Drug Therapy, Combination, Thieno[3, Efflux, Therapeutics. Pharmacology, Ethidium bromide, Synthetic compounds, medicine.drug
Abstract

We explored the antibacterial potential (alone and combination) against multidrug resistant (MDR) Pseudomonas aeruginosa isolates KG-P2 using synthesized thieno[3,2-c]pyran-2-ones in combination with different antibiotics. Out of 14 compounds, two compounds (3g and 3l) abridged the MIC of tetracycline (TET) by 16 folds. Compounds was killing the KG-P2 cells, in time dependent manner, lengthened post-antibiotic effect (PAE) of TET and found decreased the mutant prevention concentration (MPC) of TET. In ethidium bromide efflux experiment, two compounds repressed the drug transporter (efflux pumps) which is further supported by molecular docking of these compounds with efflux complex MexAB-OprM. In another study, these compounds inhibited the synthesis of biofilm.

Published
2021

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