1. Meta-analysis of Factor V Leiden G1691A polymorphism and osteonecrosis of femoral head susceptibility
- Author
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Zhengliang Luo, Qichun Zhao, Xifu Shang, Fei Hu, Xu Li, and Wenzhi Zhang
- Subjects
Oncology ,medicine.medical_specialty ,business.industry ,General Neuroscience ,Articles ,General Medicine ,Knowledge infrastructure ,medicine.disease ,Bioinformatics ,General Biochemistry, Genetics and Molecular Biology ,Femoral head ,medicine.anatomical_structure ,Polymorphism (computer science) ,Internal medicine ,Meta-analysis ,Mutation (genetic algorithm) ,Factor V Leiden ,medicine ,Gene polymorphism ,General Pharmacology, Toxicology and Pharmaceutics ,Genetic risk ,business - Abstract
Testing for genetic risk associations between Factor V Leiden (FVL) and the osteonecrosis of femoral head (ONFH) is common, however, inconsistent results have been previously obtained. To summarize results on the association of FVL mutation polymorphism with ONFH in various populations and to calculate the overall genetic risk factors, we performed a search of electronic databases including PubMed, Elsevier Science Direct, Chinese National Knowledge Infrastructure and the Chinese Biomedical Database to identify published studies correlating the FVL mutation with ONFH. Statistical analysis was performed using Review Manager (RevMan) version 5.0 and Stata statistical software (version 10). We identified 57 titles and included 7 studies comprising 481 cases and 867 controls in this meta-analysis. The groups were pooled, and a significant association between FVL mutation and increased ONFH was found (OR=4.55, 95% CI, 2.75–7.52, P
- Published
- 2013