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Your search keyword '"YUN FENG ZHOU"' showing total 2 results
Start Over Author "YUN FENG ZHOU" Journal biomedical reports
2 results on '"YUN FENG ZHOU"'

1. Expression of various protection of telomeres 1 variants is associated with telomere length and radiosensitivity in colon and gastric adenocarcinoma cells in vitro

Author

Xiao-Hong Peng, Wenbo Wang, Yun Feng Zhou, Fu Xiang Zhou, Zhi‑Guo Zhang, Haijun Yu, Conghua Xie, Hui Xu, and Han Lei

Subjects
Oncogene, Colorectal cancer, General Neuroscience, Cancer, Articles, General Medicine, Cell cycle, Biology, medicine.disease, Bioinformatics, digestive system diseases, General Biochemistry, Genetics and Molecular Biology, Telomere, Real-time polymerase chain reaction, Cancer cell, medicine, Cancer research, Radiosensitivity, General Pharmacology, Toxicology and Pharmaceutics
Abstract

Protection of telomeres 1 (POT1) is a telomere-binding protein, which binds to the single-stranded DNA extensions of telomeres and regulates telomere length. Different POT1 mRNA variants were examined and compared with telomere length and radiosensitivity in colon and gastric adenocarcinoma cells. POT1 production and telomere lengths were assessed using 10 human cancer cell lines by quantitative polymerase chain reaction (qPCR). POT1 mRNA levels, which were relatively stable, were significantly correlated with telomere length in gastric cancer cells and colon cancer cells, except for HT29 (P

Published
2015
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2. Expression of various protection of telomeres 1 variants is associated with telomere length and radiosensitivity in colon and gastric adenocarcinoma cells in vitro.

Author

HAN LEI, FU-XIANG ZHOU, HUI XU, XIAO-HONG PENG, ZHI-GUO ZHANG, WEN-BO WANG, HAI-JUN YU, CONG-HUA XIE, and YUN-FENG ZHOU

Subjects
TELOMERES, GENE expression, SINGLE-stranded DNA, GENETICS of colon cancer, STOMACH cancer, GENETICS
Abstract

Protection of telomeres 1 (POT1) is a telomere-binding protein, which binds to the single-stranded DNA extensions of telomeres and regulates telomere length. Different POT1 mRNA variants were examined and compared with telomere length and radiosensitivity in colon and gastric adenocarcinoma cells. POT1 production and telomere lengths were assessed using 10 human cancer cell lines by quantitative polymerase chain reaction (qPCR). POT1 mRNA levels, which were relatively stable, were significantly correlated with telomere length in gastric cancer cells and colon cancer cells, except for HT29 (P<0.01). POT1 v5 indexes were closely associated with radiosensitivity in colon cancer cells and gastric cancer cells (P<0.05). In conclusion, POT1 may be a good marker for the examination of cell-specific telomere length and radiosensitivity. [ABSTRACT FROM AUTHOR]

Published
2015
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