1. Molecular epidemiology of human coxsackievirus A16 strains
- Author
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Changchang Yin, Wenmin Yu, and Huanxin Xu
- Subjects
0301 basic medicine ,Foot-and-mouth disease ,Molecular epidemiology ,General Neuroscience ,030106 microbiology ,Articles ,General Medicine ,Biology ,medicine.disease ,Virology ,Molecular medicine ,General Biochemistry, Genetics and Molecular Biology ,Homology (biology) ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,stomatognathic system ,Throat ,Genotype ,medicine ,030212 general & internal medicine ,General Pharmacology, Toxicology and Pharmaceutics ,Gene ,Human coxsackievirus - Abstract
The hand, foot and mouth disease (HFMD) epidemics have mainly been caused by human enterovirus 71 and human coxsackievirus A16 (CA16), which circulated alternatively or together in the epidemic area. The aim of the present study was to provide guidance in the prevention and control of HFMD from CA16 infection. The molecular epidemiology of the human CA16 strains was investigated. Overall, 1,151 specimens (throat swabs) were collected from 1,151 patients with HFMD symptoms. The results of the homology comparison in the VP1 of CA16 strains showed that the CA16 strains belonged to the B1b subgenotype. The difference of the 6 CA16 strains analyzed showed that the most prominent strain was the A genotype, and the most close strains were the B1 gene subtype, particularly the B1b gene subtype. With regards to the amino acids, in addition to the A genotype, the differences of amino acids with other gene subtype was not significant. The present data suggest that more effective and highly targeted intervention mechanisms could be developed for the prevention and control of HFMD.
- Published
- 2016
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