1. Towards ultrahigh resolution OCT based endoscopical pituitary gland and adenoma screening: a performance parameter evaluation
- Author
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Roger Fonollà, Stefan Wolfsberger, Romana Höftberger, Wolfgang Drexler, Arthur Hosmann, Michael Winklehner, Fabian Placzek, Marco Andreana, Ryan Sentosa, Angelika Unterhuber, Alexander Micko, Rainer A. Leitgeb, and Video Coding & Architectures
- Subjects
Pituitary gland ,Adenoma ,Endoscope ,genetic structures ,01 natural sciences ,Article ,010309 optics ,03 medical and health sciences ,Optical coherence Tomography, Endoscopy, Neurosurgery ,Optical coherence tomography ,In vivo ,0103 physical sciences ,Medical imaging ,medicine ,Coherent light ,030304 developmental biology ,Tumors ,0303 health sciences ,Optical tomography ,medicine.diagnostic_test ,business.industry ,Brain ,Endoscopy ,medicine.disease ,Atomic and Molecular Physics, and Optics ,eye diseases ,medicine.anatomical_structure ,Ultrahigh resolution ,sense organs ,business ,Ex vivo ,Biomarkers ,Biotechnology ,Biomedical engineering - Abstract
Ultrahigh resolution optical coherence tomography (UHR-OCT) for differentiating pituitary gland versus adenoma tissue has been investigated for the first time, indicating more than 80% accuracy. For biomarker identification, OCT images of paraffin embedded tissue are correlated to histopathological slices. The identified biomarkers are verified on fresh biopsies. Additionally, an approach, based on resolution modified UHR-OCT ex vivo data, investigating optical performance parameters for the realization in an in vivo endoscope is presented and evaluated. The identified morphological features–cell groups with reticulin framework–detectable with UHR-OCT showcase a promising differentiation ability, encouraging endoscopic OCT probe development for in vivo application.
- Published
- 2020
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