1. Resolving tissue chromophore concentration at MRI resolution using multi-wavelength photo-magnetic imaging
- Author
-
Farouk Nouizi, Mehmet Burcin Unlu, Seunghoon Ha, Alex Luk, Hakan Erkol, M. Al-Garawi, and Gultekin Gulsen
- Subjects
0303 health sciences ,Materials science ,genetic structures ,business.industry ,Resolution (electron density) ,Chromophore ,Laser ,01 natural sciences ,Article ,Atomic and Molecular Physics, and Optics ,Imaging phantom ,Diffuse optical imaging ,law.invention ,010309 optics ,03 medical and health sciences ,Wavelength ,Optics ,law ,0103 physical sciences ,business ,Absorption (electromagnetic radiation) ,Preclinical imaging ,030304 developmental biology ,Biotechnology - Abstract
Photo-magnetic imaging (PMI) is an emerging optical imaging modality that showed great performance on providing absorption maps with high resolution and quantitative accuracy. As a multi-modality technology, PMI warms up the imaged object using a near infrared laser while temperature variation is measured using magnetic resonance imaging. By probing tissue at multiple wavelengths, concentration of the main tissue chromophores such as oxy-and deoxy-hemoglobin, lipid, and water are obtained then used to derive functional parameters such as total hemoglobin concentration and relative oxygen saturation. In this paper, we present a multi-wavelength PMI system that was custom-built to host five different laser wavelengths. After recovering the high-resolution absorption maps, a least-squared minimization process was used to resolve the different chromophore concentration. The performance of the system was experimentally tested on a phantom with two different dyes. Their concentrations were successfully assessed with high spatial resolution and average accuracy of nearly 80%. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
- Published
- 2020
- Full Text
- View/download PDF