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Start Over Author "T H, Risby" Journal biomedical mass spectrometry
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1. Monitoring normal and malignant human white blood cells by the use of linear programmed thermal degradation mass spectrometry

Author

T. H. Risby, Harvey M. Golomb, and A. L. Yergey

Subjects
Controlled degradation, Ions, Leukemia, Hairy Cell, Leukemia, Chemistry, Computers, Analytical chemistry, Mass spectrometry, Molecular biology, Mass Spectrometry, Leukemia, Lymphoid, White (mutation), Leukemia, Myeloid, Acute, Leukocytes, Malignant cells, Humans, Lymphocytes, Spectroscopy, Granulocytes
Abstract

A new methodology has been applied to the analysis of human white blood cells obtained both from donors with normal white cells and from donors having one of several cytologically identified leukemias. The analytical process makes use of evolution patterns of molecular fragments generated during the well controlled degradation of the cells. The process has been shown to be effective both in grouping together malignant cells that originate from the same diseases and in distinguishing between malignant cells originating from different diseases. The reproducibility of the method has been demonstrated.

Published
1978

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