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Start Over Author "Cheng, Shaobing" Journal biomed research international
3 results on '"Cheng, Shaobing"'

3. BAG3 and HIF-1 α coexpression detected by immunohistochemistry correlated with prognosis in hepatocellular carcinoma after liver transplantation.

Author

Xiao H, Tong R, Cheng S, Lv Z, Ding C, Du C, Xie H, Zhou L, Wu J, and Zheng S

Subjects
Adult, Biomarkers, Tumor biosynthesis, Carcinoma, Hepatocellular pathology, Female, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, Liver Neoplasms pathology, Liver Transplantation, Male, Middle Aged, Prognosis, Adaptor Proteins, Signal Transducing biosynthesis, Apoptosis Regulatory Proteins biosynthesis, Carcinoma, Hepatocellular genetics, Hypoxia-Inducible Factor 1, alpha Subunit biosynthesis, Liver Neoplasms genetics
Abstract

Objective: The objective is to determine the effects of BAG3 and HIF-1 α expression on the prognosis of HCC patients after liver transplantation., Methods: Samples from 31 patients with HCC receiving liver transplantation were collected for this study. The immunohistochemistry was used to detect the expression of BAG3 and HIF-1 α of HCC samples., Results: According to the immunohistochemistry results, BAG3 and HIF-1 α staining were significantly associated with tumor TNM stage (P = 0.004, P = 0.012). A significant association between high BAG3/HIF-1 α levels and a shorter overall survival was detected, so as the combined BAG3 and HIF-1 α analysis., Conclusion: The results suggested that the expression level of BAG3 and HIF-1 α is efficient prognostic parameters in patients with HCC after liver transplantation.

Published
2014
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