1. Modulation of the Antibiotic Activity by Extracts from Amburana cearensis A. C. Smith and Anadenanthera macrocarpa (Benth.) Brenan
- Author
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Daniel Luna Lucetti, Gardênia Mª Martins de Oliveira, Patrícia Rosane Leite de Figueiredo, Edinardo F.F. Matias, Cassio R. Medeiros, Emerson O. Ferreira, Fernando Gomes Figueredo, Elaine Cristina Pereira Lucetti, Marta Regina Kerntopf, Cícero M. G. Torres, Júlio C. F. Silva, Irwin Rose Alencar de Menezes, João Marcos Ferreira de Lima Silva, José Galberto Martins da Costa, Bruno F. F. Lucena, Henrique Douglas Melo Coutinho, Francisco A. V. Santos, and Aracélio Viana Colares
- Subjects
Staphylococcus aureus ,Mimosa ,Article Subject ,lcsh:Medicine ,Microbial Sensitivity Tests ,Biology ,Bronquite ,beta-Lactams ,medicine.disease_cause ,General Biochemistry, Genetics and Molecular Biology ,Microbiology ,Minimum inhibitory concentration ,Drug Resistance, Bacterial ,Escherichia coli ,Anadenanthera ,medicine ,Amikacin ,Asma ,General Immunology and Microbiology ,Traditional medicine ,Plant Extracts ,lcsh:R ,Fabaceae ,General Medicine ,Antimicrobial ,biology.organism_classification ,Anti-Bacterial Agents ,Plant Leaves ,Aminoglycosides ,Amburana cearensis ,Ampicillin ,Antagonism ,Antibacterial activity ,Research Article ,medicine.drug - Abstract
The aim of this study was to verify the possible interactions between ethanol extracts ofAmburana cearensisA. C. Smith andAnadenanthera macrocarpa(Benth.) Brenan, combined with six antimicrobial drugs against multiresistant strains ofStaphylococcus aureusandEscherichia coliisolated from humans. The antibacterial activity of the extracts was determined using the minimum inhibitory concentration (MIC). The microdilution assay was performed to verify the interactions between the natural products and the antibiotics using a subinhibitory concentration. The activity of amikacin associated with the extract ofAnadenanthera macrocarpaagainst EC 27 was enhanced, demonstrating an MIC reduction from 128 to 4 μg/mL. Among theβ-lactams, no potentiation on its activity was observed, with exception to the antagonism of the natural products with ampicillin againstS. aureus358.
- Published
- 2013
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