1. Modifications in lipid levels are independent of serum TNF-α in rheumatoid arthritis: results of an observational 24-week cohort study comparing patients receiving etanercept plus methotrexate or methotrexate as monotherapy
- Author
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Mónica Vázquez-Del Mercado, Carlos E. Garcia-Gonzalez, Benjamín Trujillo-Hernández, Jorge I. Gamez-Nava, Mario Salazar-Páramo, Evangelina Varon-Villalpando, Karina Patricia Ayala-Lopez, Alberto Daniel Rocha-Muñoz, José Clemente Vásquez-Jiménez, Adolfo R. Cota-Sanchez, EM Olivas-Flores, Norma Alejandra Rodriguez-Jimenez, Erika Anita Aguilar-Chavez, Esther Guadalupe Corona-Sanchez, Laura Gonzalez-Lopez, and Ernesto Germán Cardona-Muñoz
- Subjects
musculoskeletal diseases ,Adult ,Male ,medicine.medical_specialty ,Article Subject ,lcsh:Medicine ,Pharmacology ,Gastroenterology ,General Biochemistry, Genetics and Molecular Biology ,Immunoglobulin G ,Receptors, Tumor Necrosis Factor ,Etanercept ,Arthritis, Rheumatoid ,Internal medicine ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,skin and connective tissue diseases ,General Immunology and Microbiology ,biology ,business.industry ,Tumor Necrosis Factor-alpha ,lcsh:R ,General Medicine ,Middle Aged ,medicine.disease ,Lipids ,Antirheumatic Agents ,Methotrexate ,Rheumatoid arthritis ,biology.protein ,Clinical Study ,Tumor necrosis factor alpha ,lipids (amino acids, peptides, and proteins) ,Drug Therapy, Combination ,Female ,business ,medicine.drug ,Cohort study - Abstract
Objective.To compare the modifications in lipids between patients with rheumatoid arthritis (RA) receiving etanercept plus methotrexate (ETA + MTX) versus methotrexate (MTX) and their relationship with serum levels of tumor necrosis factor-alpha (TNF-α).Methods.In an observational cohort study, we compared changes in lipid levels in patients receiving ETA + MTX versus MTX in RA. These groups were assessed at baseline and at 4 and 24 weeks, measuring clinical outcomes, total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, and TNF-α.Results.Baseline values for lipid levels were similar in both groups. HDL-C levels increased significantly only in the ETA + MTX group (from 45.5 to 50.0 mg/dL at 4 weeks, a 10.2% increase,P<0.001, and to 56.0 mg/dL at 24 weeks, a 25.1% increase,P<0.001), while other lipids underwent no significant changes. ETA + MTX also exhibited a significant increase in TNF-α (44.8 pg/mL at baseline versus 281.4 pg/mL at 24 weeks,P<0.001). The MTX group had no significant changes in lipids or TNF-α. Significant differences in HDL-C between groups were observed at 24 weeks(P=0.04)and also in TNF-α (P=0.01).Conclusion.HDL-C levels increased significantly following treatment with ETA + MTX, without a relationship with decrease of TNF-α.
- Published
- 2014