1. Antioxidant properties of ALD grown nanoceria films with tunable valency
- Author
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Ankur Gupta, Akihiro Kushima, Craig J. Neal, Supriya Koul, Sudipta Seal, Sushant Singh, and Tamil S. Sakthivel
- Subjects
Cerium oxide ,Materials science ,Biomedical Engineering ,Nanoparticle ,Apoptosis ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Antioxidants ,Cell Line ,Catalysis ,law.invention ,Atomic layer deposition ,Magazine ,law ,Humans ,Nanotechnology ,General Materials Science ,Particle Size ,Valence (chemistry) ,Valency ,Cerium ,Hydrogen Peroxide ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Chemical engineering ,Nanoparticles ,0210 nano-technology ,Science, technology and society - Abstract
Herein, we provide the first account of a method to control cerium oxide's mixed valence states (as Ce3+ to Ce4+ ratio) in ultra-thin films formed via atomic layer deposition (ALD). It is determined that modulation of Ce3+/Ce4+ ratio occurs with respect to film thickness and is analogous to the change in surface chemistry observed for cerium oxide nanoparticles with varying particle diameter. The influence of film thickness on enzyme-mimetic radical scavenging is also characterized. Higher film thicknesses show 9-fold increase in catalytic activity. In vitro biocompatibility (apoptosis < 4%) and electrochemical biosensing (lowest concentration: 18 ppt) studies were performed to demonstrate the potential of ALD-grown nanoceria films for biomedical applications.
- Published
- 2019
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