1. Degradation of poly(ester) microspheres
- Author
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Harvey D. Palmer, Eric A. Schmitt, Robert J. Linhardt, Douglas R. Flanagan, and H.T. Wang
- Subjects
Magnetic Resonance Spectroscopy ,Materials science ,Polyesters ,Ion chromatography ,Biophysics ,Bioengineering ,Biomaterials ,Gel permeation chromatography ,chemistry.chemical_compound ,Polymer chemistry ,Copolymer ,chemistry.chemical_classification ,Lactide ,Viscosity ,Proteins ,Polymer ,Microspheres ,Molecular Weight ,Polyester ,Biodegradation, Environmental ,Monomer ,chemistry ,Chemical engineering ,Mechanics of Materials ,Delayed-Action Preparations ,Spray drying ,Microscopy, Electron, Scanning ,Ceramics and Composites - Abstract
Biodegradable polymeric microspheres have been prepared by spray drying, precipitation, rotary evaporation and press grinding methods. Erosion of microspheres of poly(lactide), poly(3-hydroxybutyrate), copolymers of lactide and glycolide, and copolymers of 3-hydroxybutyrate and 3-hydroxyvalerate at 85 degrees C and 37 degrees C have been studied using ion chromatography, nuclear magnetic resonance, residual mass measurements, viscometry and gel permeation chromatography. Such studies demonstrated that these polyester matrices degraded via (1) random chain scission and (2) release of soluble monomeric and oligomeric products. Protein release from microspheres prepared by these methods indicated that most of the protein is released before the polymer matrix loses weight.
- Published
- 1990
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