1. Polymeric micelles: Theranostic co-delivery system for poorly water-soluble drugs and contrast agents
- Author
-
Praveen Kulkarni, Srinivas Sridhar, Vladimir P. Torchilin, Jaydev R. Upponi, Kaushal Jerajani, Dattatri Nagesha, and Craig F. Ferris
- Subjects
Male ,Paclitaxel ,Polymers ,Biophysics ,Nanoparticle ,Contrast Media ,Bioengineering ,Apoptosis ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Micelle ,Theranostic Nanomedicine ,Article ,Biomaterials ,chemistry.chemical_compound ,Drug Delivery Systems ,Cell Line, Tumor ,Neoplasms ,medicine ,Animals ,Magnetite Nanoparticles ,Micelles ,Co delivery ,Mice, Inbred BALB C ,Polymeric micelles ,Melanoma ,Cancer ,Water ,021001 nanoscience & nanotechnology ,medicine.disease ,Magnetic Resonance Imaging ,0104 chemical sciences ,Mice, Inbred C57BL ,chemistry ,Solubility ,Mechanics of Materials ,Drug delivery ,Ceramics and Composites ,Female ,0210 nano-technology - Abstract
Interest in theranostic agents has continued to grow because of their promise for simultaneous cancer detection and therapy. A platform-based nanosized combination agent suitable for the enhanced diagnosis and treatment of cancer was prepared using polymeric polyethylene glycol-phosphatidylethanolamine-based micelles loaded with both, poorly soluble chemotherapeutic agent paclitaxel and hydrophobic superparamagnetic iron oxide nanoparticles (SPION), a Magnetic Resonance Imaging contrast agent. The co-loaded paclitaxel and SPION did not affect each other's functional properties in vitro. In vivo, the resulting paclitaxel-SPION-co-loaded PEG-PE micelles retained their Magnetic Resonance contrast properties and apoptotic activity in breast and melanoma tumor mouse models. Such theranostic systems are likely to play a significant role in the combined diagnosis and therapy that leads to a more personalized and effective form of treatment.
- Published
- 2017