1. RAS mutation prevalence among patients with metastatic colorectal cancer: a meta-analysis of real-world data
- Author
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Hal Westhead, Mario Barugel, Piotr Wójcik, Pavel Fabian, Nikolaos Gouvas, J. Han van Krieken, Zuzana Traugottová, Samuel S. Murray, George Kafatos, Edit Molnar, Hana Vošmiková, Daniela Niepel, Sophie Jenkins-Anderson, Erika Toth, Antonios Bilalis, Tamer Garawin, Kimberley Lowe, George Papaxoinis, Nadia Mokhtar, Andrzej Tysarowski, Jörg Trojan, A. Skálová, and József Tímár
- Subjects
Proto-Oncogene Proteins B-raf ,0301 basic medicine ,Neuroblastoma RAS viral oncogene homolog ,Oncology ,medicine.medical_specialty ,Colorectal cancer ,education ,prevalence ,Clinical Biochemistry ,NRAS ,Bioinformatics ,medicine.disease_cause ,BRAF ,Proto-Oncogene Proteins p21(ras) ,03 medical and health sciences ,Tumor Status ,0302 clinical medicine ,Internal medicine ,Drug Discovery ,Biomarkers, Tumor ,KRAS ,medicine ,Humans ,business.industry ,metastatic colorectal cancer ,Biochemistry (medical) ,real world ,Exons ,medicine.disease ,anti-EGFR ,Survival Rate ,030104 developmental biology ,mCRC ,030220 oncology & carcinogenesis ,Meta-analysis ,Mutation ,RAS Mutation ,Observational study ,Colorectal Neoplasms ,business ,Real world data ,Research Article ,RAS - Abstract
Aim: A confirmed wild-type RAS tumor status is commonly required for prescribing anti-EGFR treatment for metastatic colorectal cancer. This noninterventional, observational research project estimated RAS mutation prevalence from real-world sources. Materials & methods: Aggregate RAS mutation data were collected from 12 sources in three regions. Each source was analyzed separately; pooled prevalence estimates were then derived from meta-analyses. Results: The pooled RAS mutation prevalence from 4431 tumor samples tested for RAS mutation status was estimated to be 43.6% (95% CI: 38.8–48.5%); ranging from 33.7% (95% CI: 28.4–39.3%) to 54.1% (95% CI: 51.7–56.5%) between sources. Conclusion: The RAS mutation prevalence estimates varied among sources. The reasons for this are not clear and highlight the need for further research.
- Published
- 2017
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