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Context: The mechanism of nickel-induced pathogenesis remains elusive., Objective: To examine effects of nickel exposure on plasma oxidative and anti-oxidative biomarkers., Materials and Methods: Biomarker data were collected from 154 workers with various levels of nickel exposure and from 73 controls. Correlations between nickel exposure and oxidative and anti-oxidative biomarkers were determined using linear regression models., Results: Workers with a exposure to high nickel levels had significantly lower levels of anti-oxidants (glutathione and catalase) than those with a lower exposure to nickel; however, only glutathione showed an independent association after multivariable adjustment., Discussion and Conclusion: Exposure to high levels of nickel may reduce serum anti-oxidative capacity.