1. Cancer antigen-125 levels predict long-term mortality in chronic obstructive pulmonary disease
- Author
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Omer Tamer Dogan, Ali Zorlu, Gülay Aydın, Hakki Kaya, Mehmet Yilmaz, Tarik Kivrak, Hasan Yucel, Savaş Sarıkaya, [Kaya, Hakki -- Zorlu, Ali -- Yucel, Hasan -- Yilmaz, Mehmet Birhan] Cumhuriyet Univ, Sch Med, Dept Cardiol, Sivas, Turkey -- [Dogan, Omer Tamer] Cumhuriyet Univ, Sch Med, Dept Chest Dis, Sivas, Turkey -- [Sarikaya, Savas] Bozok Univ, Sch Med, Dept Cardiol, Yozgat, Turkey -- [Aydin, Gulay] Unye State Hosp, Dept Cardiol, Ordu, Turkey -- [Kivrak, Tarik] Sivas State Hosp, Dept Cardiol, Sivas, Turkey, YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628, and YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628
- Subjects
Male ,medicine.medical_specialty ,Time Factors ,Exacerbation ,Health, Toxicology and Mutagenesis ,Clinical Biochemistry ,Pulmonary disease ,risk stratification ,Kaplan-Meier Estimate ,Risk Assessment ,Biochemistry ,Gastroenterology ,chronic obstructive pulmonary disease ,Immunoenzyme Techniques ,Pulmonary Disease, Chronic Obstructive ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,Humans ,Medicine ,Prospective Studies ,CA-125 ,Lung ,Aged ,Proportional Hazards Models ,Aged, 80 and over ,COPD ,business.industry ,Cancer ,Middle Aged ,Prognosis ,medicine.disease ,Respiratory Function Tests ,Surgery ,Survival Rate ,Cancer antigen ,cancer antigen-125 ,CA-125 Antigen ,Multivariate Analysis ,Risk stratification ,long-term mortality ,Disease Progression ,Biomarker (medicine) ,Female ,Long term mortality ,business ,Biomarkers - Abstract
WOS: 000358062100010, PubMed ID: 25986074, Background: Cancer antigen-125 (CA-125) might be a useful biomarker to predict long-term mortality in patients with recent exacerbation of chronic obstructive pulmonary disease (COPD). Methods: A total of 87 consecutive patients with COPD were evaluated prospectively. Mean age of patients was 68 +/- 10 years (55% males, 45% females) with a median follow-up period of 49 months. Optimal cut-off value of CA-125 to predict mortality was found as >93.34 U/ml, with 91% specificity and 40% sensitivity. Results: After follow-up, 20 out of 87 (23%) experienced cardiovascular death. CA-125 levels were higher among those who died compared to those who survived [55 (12-264) versus 28 (5-245) U/ml, p = 0.013]. In multivariate Cox proportional-hazards model with forward stepwise method, only CA-125 > 93.34 U/ml on admission (HR 3.713, 95% Cl: 1.035-13.323, p = 0.044) remained associated with an increased risk of death. Conclusions: For the first time, we demonstrated that CA-125 helps the risk stratification of patients with COPD.
- Published
- 2015