1. Supramolecular Hydrogels Exhibiting Fast In Situ Gel Forming and Adjustable Degradation Properties
- Author
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Kyung Min Park, Eugene Lih, Ki Dong Park, Ngoc Quyen Tran, and Yoon Ki Joung
- Subjects
Magnetic Resonance Spectroscopy ,Polymers and Plastics ,Biocompatibility ,Supramolecular chemistry ,Tyramine ,Bioengineering ,macromolecular substances ,Horseradish peroxidase ,Biomaterials ,Chitosan ,Mice ,chemistry.chemical_compound ,X-Ray Diffraction ,Polymer chemistry ,Materials Chemistry ,Animals ,Horseradish Peroxidase ,chemistry.chemical_classification ,Molecular Structure ,Cyclodextrin ,biology ,technology, industry, and agriculture ,Hydrogels ,Hydrogen Peroxide ,Polymer ,chemistry ,Chemical engineering ,Self-healing hydrogels ,Drug delivery ,NIH 3T3 Cells ,biology.protein - Abstract
Fast in situ forming supramolecular hydrogels consisted of the tyramine-conjugated supramolecular structures and chitosan derivative were prepared via an enzymatic reaction with horseradish peroxidase (HRP) and hydrogen peroxide (H(2)O(2)). The gel formation was varied within a time period of 5 s to 10 min by controlling the concentrations of HRP, H(2)O(2), and polymers. Tyramine conjugation at different sites of the supramolecular structure resulted in significant changes in physical properties and the degradation time of the hydrogels that were confirmed by water uptake, compressive strength and degradation tests. In addition, the hydrogels showed a good cytocompatibility in vitro. These hydrogels could be promising injectable biomaterials with adjustable degradation times to control both the cellular behaviors as a regenerative cell matrix and the drug release behavior as a drug delivery vehicle.
- Published
- 2010