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Start Over Author "Jose Strauss" Journal biology of the neonate
2 results on '"Jose Strauss"'

1. Single-dose captopril scintigraphy in the neonate with renovascular hypertension: prediction of renal failure, a side effect of captopril therapy

Author

Ana Paredes, Efrosyni Sfakianaki, Ronald N. Goldberg, George N. Sfakianakis, Carolyn Abitbol, Gaston Zilleruelo, and Jose Strauss

Subjects
Male, medicine.medical_specialty, Captopril, Side effect, Urology, Scintigraphy, Kidney, Umbilical cord, Umbilical Arteries, Renovascular hypertension, Catheterization, Medicine, Humans, Ultrasonics, cardiovascular diseases, Radionuclide Imaging, biology, medicine.diagnostic_test, business.industry, Infant, Newborn, Angiotensin-converting enzyme, Acute Kidney Injury, medicine.disease, Surgery, medicine.anatomical_structure, Hypertension, Renovascular, Pediatrics, Perinatology and Child Health, Toxicity, biology.protein, Female, business, Aortic thrombosis, circulatory and respiratory physiology, Developmental Biology, medicine.drug
Abstract

Baseline and single-dose captopril scintigraphy with 1 mCi of 99mTc-diethylene-triamine-pentaacetic acid (or 99mTc-glucoheptonate) was performed in 5 neonates with renovascular hypertension. Unilateral renal artery thrombosis and/or renal infarction was associated with severe impairment or lack of function on both studies (3 patients). Renal ischemia due to aortic thrombus manifested itself as lack of function only following captopril (2 patients). This approach predicted renal failure as a side effect of captopril therapy in 2 patients, 1 with unilateral (contralateral kidney infarcted) and the other with bilateral renal ischemia from aortic thrombus. Single-dose captopril scintigraphy may be a useful tool to predict tolerance to captopril therapy.

Published
1988

2. Renal bicarbonate handling in low birth weight infants during metabolic acidosis

Author

Jose Strauss, Eduardo Bancalari, Gaston Zilleruelo, Shahid Sultan, and Bernard Steele

Subjects
Male, medicine.medical_specialty, Bicarbonate, Sodium, chemistry.chemical_element, Urine, Kidney, Excretion, chemistry.chemical_compound, Internal medicine, medicine, Humans, Acidosis, urogenital system, business.industry, Infant, Newborn, Metabolic acidosis, Carbon Dioxide, Hydrogen-Ion Concentration, Infant, Low Birth Weight, medicine.disease, Low birth weight, Bicarbonates, Endocrinology, medicine.anatomical_structure, Blood, Sodium Bicarbonate, chemistry, Pediatrics, Perinatology and Child Health, Base excess, medicine.symptom, business, Developmental Biology
Abstract

We studied the fractional excretion of bicarbonate (FE HCO3) in 10 low birth weight infants aged 1–6 days during metabolic acidosis (base excess ≥ ––5 mEq/l) and during subsequent sodium HCO3 infusion. The mean birth weight was 1,095 g; the mean gestational age was 29 weeks. The ability to decrease urine pH to < 5.5 and FE HCO3 to < 1 % during metabolic acidosis was not limited by low gestational age or birth weight. After HCO3 therapy, all infants corrected their negative base excess, and plasma HCO3 increased significantly. All infants with blood pH ≤ 7.22 or PaCO2 ≥ 50 mm Hg had minimal or absent FE HCO3. Infants with elevated PaCO2 and mild or absent acidosis also had complete HCO3 tubular reabsorption. These results suggest that the HCO3 tubular reabsorption is adequate during metabolic and/or respiratory acidosis in low birth weight infants.

Published
1986

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