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Start Over Author "Maria Agnese Sabatini" Journal biology of the cell
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1. Relationship between growth inhibition and mitochondrial function in petite-negative yeasts. II. Effects of central nervous system drugs upon pathogenic and non-pathogenic Candida species

Author

G. Truzzi, P. P. Puglisi, C. Ferrari, N. Marmiroli, Maria Agnese Sabatini, and F. Tedeschi

Subjects
Nervous system, Chlorpheniramine, Imipramine, Cytochrome, Chlorpromazine, Amitriptyline, Antidepressive Agents, Tricyclic, Mitochondrion, Biology, chemistry.chemical_compound, Oxygen Consumption, Biosynthesis, medicine, Petite-negative yeasts, Mitosis, Promazine, Candida, pathogenic yeasts, CNS drugs, mitochondria, Cell Biology, General Medicine, Corpus albicans, Yeast, Mitochondria, medicine.anatomical_structure, chemistry, Biochemistry, Clomipramine, biology.protein, Cytochromes, Electrophoresis, Polyacrylamide Gel, Growth inhibition, Cell Division, Antipsychotic Agents
Abstract

Six nervous system drugs which inhibited vegetative reproduction of S. cerevisiae arrested also mitotic division of C. utilis, C. albicans and C. tropicalis. Chlorpromazine and chlorpheniramine which proved to be the most effective, affected respiration and cytochrome biosynthesis. Electrophoretic bands with MW congruent to 100 K were faint in silver-stained electrophoregrams of proteins from cells grown in the presence of a sub-inhibitory concentration of chlorpromazine.

Published
1985

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