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Your search keyword '"Inoue, Kimiko"' showing total 32 results
Start Over Author "Inoue, Kimiko" Journal biology of reproduction
32 results on '"Inoue, Kimiko"'

1. Improved development of mouse somatic cell nuclear transfer embryos by chlamydocin analogues, class I and IIa histone deacetylase inhibitors†

Author

Kamimura, Satoshi, primary, Inoue, Kimiko, additional, Mizutani, Eiji, additional, Kim, Jin-Moon, additional, Inoue, Hiroki, additional, Ogonuki, Narumi, additional, Miyamoto, Kei, additional, Ihashi, Shunya, additional, Itami, Nobuhiko, additional, Wakayama, Teruhiko, additional, Ito, Akihiro, additional, Nishino, Norikazu, additional, Yoshida, Minoru, additional, and Ogura, Atsuo, additional

Published
2021
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3. Development of assisted reproductive technologies for Mus spretus†

Author

Hasegawa, Ayumi, Mochida, Keiji, Matoba, Shogo, Inoue, Kimiko, Hama, Daiki, Kadota, Masayo, Hiraiwa, Noriko, Yoshiki, Atsushi, and Ogura, Atsuo

Abstract

The genus Musconsists of many species with high genetic diversity. However, only one species, Mus musculus(the laboratory mouse), is common in biomedical research. The unavailability of assisted reproductive technologies (ARTs) for other Musspecies might be a major reason for their limited use in laboratories. Here, we devised ARTs for Mus spretus(the Algerian mouse), a commonly used wild-derived Musspecies. We found that in vitro production of M. spretusembryos was difficult because of low efficacies of superovulation with equine chorionic gonadotropin or anti-inhibin serum (AIS) (5–8 oocytes per female) and a low fertilization rate following in vitro fertilization (IVF; 15.2%). The primary cause of this was the hardening of the zona pellucida but not the sperm’s fertilizing ability, as revealed by reciprocal IVF with laboratory mice. The largest number of embryos (16 per female) were obtained when females were injected with AIS followed by human chorionic gonadotropin and estradiol injections 24 h later, and then by natural mating. These in vivo-derived 2-cell embryos could be vitrified/warmed with a high survival rate (94%) using an ethylene glycol-based solution. Importantly, more than 60% of such embryos developed into healthy offspring following interspecific embryo transfer into (C57BL/6 × C3H) F1 female mice. Thus, we have devised practical ARTs for Mus spretusmice, enabling efficient production of embryos and animals, with safe laboratory preservation of their strains. In addition, we have demonstrated that interspecific embryo transfer is possible in murine rodents.Embryos from wild-derived Mus spretusmice can be efficiently produced, cryopreserved, and transferred into laboratory mouse females using newly developed assisted reproductive technology protocols.

Published
2021
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5. Generation of Cloned Mice from Adult Neurons by Direct Nuclear Transfer1

Author

Mizutani, Eiji, primary, Oikawa, Mami, additional, Kassai, Hidetoshi, additional, Inoue, Kimiko, additional, Shiura, Hirosuke, additional, Hirasawa, Ryutaro, additional, Kamimura, Satoshi, additional, Matoba, Shogo, additional, Ogonuki, Narumi, additional, Nagatomo, Hiroaki, additional, Abe, Kuniya, additional, Wakayama, Teruhiko, additional, Aiba, Atsu, additional, and Ogura, Atsuo, additional

Published
2015
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6. Establishment of Paternal Genomic Imprinting in Mouse Prospermatogonia Analyzed by Nuclear Transfer1

Author

Kamimura, Satoshi, primary, Hatanaka, Yuki, additional, Hirasawa, Ryutaro, additional, Matsumoto, Kazuya, additional, Oikawa, Mami, additional, Lee, Jiyoung, additional, Matoba, Shogo, additional, Mizutani, Eiji, additional, Ogonuki, Narumi, additional, Inoue, Kimiko, additional, Kohda, Takashi, additional, Ishino, Fumitoshi, additional, and Ogura, Atsuo, additional

Published
2014
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7. Mouse Cloning Using a Drop of Peripheral Blood1

Author

Kamimura, Satoshi, primary, Inoue, Kimiko, additional, Ogonuki, Narumi, additional, Hirose, Michiko, additional, Oikawa, Mami, additional, Yo, Masahiro, additional, Ohara, Osamu, additional, Miyoshi, Hiroyuki, additional, and Ogura, Atsuo, additional

Published
2013
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13. Pluripotency of a Single Spermatogonial Stem Cell in Mice1

Author

Kanatsu-Shinohara, Mito, primary, Lee, Jiyoung, additional, Inoue, Kimiko, additional, Ogonuki, Narumi, additional, Miki, Hiromi, additional, Toyokuni, Shinya, additional, Ikawa, Masahito, additional, Nakamura, Tomoyuki, additional, Ogura, Atsuo, additional, and Shinohara, Takashi, additional

Published
2008
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14. Production of Functional Spermatids from Mouse Germline Stem Cells in Ectopically Reconstituted Seminiferous Tubules1

Author

Kita, Kaoru, primary, Watanabe, Takeshi, additional, Ohsaka, Kimito, additional, Hayashi, Hirofumi, additional, Kubota, Yoshinobu, additional, Nagashima, Yoji, additional, Aoki, Ichiro, additional, Taniguchi, Hideki, additional, Noce, Toshiaki, additional, Inoue, Kimiko, additional, Miki, Hiromi, additional, Ogonuki, Narumi, additional, Tanaka, Hiromitsu, additional, Ogura, Atsuo, additional, and Ogawa, Takehiko, additional

Published
2007
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21. The Novel Dominant Mutation Dspd Leads to a Severe Spermiogenesis Defect in Mice1

Author

Kai, Masayuki, primary, Irie, Masahito, additional, Okutsu, Tomohisa, additional, Inoue, Kimiko, additional, Ogonuki, Narumi, additional, Miki, Hiromi, additional, Yokoyama, Minesuke, additional, Migishima, Rika, additional, Muguruma, Kaori, additional, Fujimura, Hisako, additional, Kohda, Takashi, additional, Ogura, Atsuo, additional, Kaneko-Ishino, Tomoko, additional, and Ishino, Fumitoshi, additional

Published
2004
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26. The Novel Dominant Mutation DspdLeads to a Severe Spermiogenesis Defect in Mice1

Author

Kai, Masayuki, Irie, Masahito, Okutsu, Tomohisa, Inoue, Kimiko, Ogonuki, Narumi, Miki, Hiromi, Yokoyama, Minesuke, Migishima, Rika, Muguruma, Kaori, Fujimura, Hisako, Kohda, Takashi, Ogura, Atsuo, Kaneko-Ishino, Tomoko, and Ishino, Fumitoshi

Abstract

Spermiogenesis is a complex process that is regulated by a plethora of genes and interactions between germ and somatic cells. Here we report a novel mutant mouse strain that carries a transgene insertional/translocational mutation and exhibits dominant male sterility. We named the mutation dominant spermiogenesis defect (Dspd). In the testes of Dspdmutant mice, spermatids detached from the seminiferous epithelium at different steps of the differentiation process before the completion of spermiogenesis. Microinsemination using spermatids collected from the mutant testes resulted in the birth of normal offspring. These observations indicate that the major cause of Dspdinfertility is (are) a defect(s) in the Sertoli cell-spermatid interaction or communication in the seminiferous tubules. Fluorescent in situ hybridization (FISH) analysis revealed a translocation between chromosomes 7F and 14C at the transgene insertion site. The deletion of a genomic region of chromosome 7F greater than 1 megabase and containing at least six genes (Cttn, Fadd, Fgf3, Fgf4, Fgf15,and Ccnd1) was associated with the translocation. Cttnencodes the actin-binding protein cortactin. Immunohistochemical analysis revealed localization of cortactin beside elongated spermatids in wild-type testes; abnormality of cortactin localization was found in mutant testes. These data suggest an important role of cortactin in Sertoli cell-spermatid interactions and in the Dspdphenotype.

Published
2004
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27. Effects of Donor Cell Type and Genotype on the Efficiency of Mouse Somatic Cell Cloning1

Author

Inoue, Kimiko, Ogonuki, Narumi, Mochida, Keiji, Yamamoto, Yoshie, Takano, Kaoru, Kohda, Takashi, Ishino, Fumitoshi, and Ogura, Atsuo

Abstract

Although it is widely assumed that the cell type and genotype of the donor cell affect the efficiency of somatic cell cloning, little systematic analysis has been done to verify this assumption. The present study was undertaken to examine whether donor cell type, donor genotype, or a combination thereof increased the efficiency of mouse cloning. Initially we assessed the developmental ability of embryos that were cloned from cumulus or immature Sertoli cells with six different genotypes (i.e., 2 × 6 factorial). Significantly better cleavage rates were obtained with cumulus cells than with Sertoli cells (P< 0.005, two-way ANOVA), which probably was due to the superior cell-cycle synchrony of cumulus cells at G0/G1. After embryo transfer, there was a significant effect of cell type on the birth rate, with Sertoli cells giving the better result (P< 0.005). Furthermore, there was a significant interaction (P< 0.05) between the cell type and genotype, which indicates that cloning efficiency is determined by a combination of these two factors. The highest mean birth rate (10.8 ± 2.1%) was obtained with (B6 × 129)F1 Sertoli cells. In the second series of experiments, we examined whether the developmental ability of clones with the wild-type genotype (JF1) was improved when combined with the 129 genotype. Normal pups were cloned from cumulus and immature Sertoli cells of the (129 × JF1)F1 and (JF1 × 129)F1 genotypes, whereas no pups were born from cells with the (B6 × JF1)F1 genotype. The present study clearly demonstrates that the efficiency of somatic cell cloning, and in particular fetal survival after embryo transfer, may be improved significantly by choosing the appropriate combinations of cell type and genotype.

Published
2003
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