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Start Over Author "A. Balduzzi" Journal biology of blood and marrow transplantation
24 results on '"A. Balduzzi"'

2. Transplantation in Children and Adolescents with Acute Lymphoblastic Leukemia from a Matched Donor versus an HLA-Identical Sibling: Is the Outcome Comparable? Results from the International BFM ALL SCT 2007 Study

Author

Balduzzi, Adriana, Dalle, Jean-Hugues, Wachowiak, Jacek, Yaniv, Isaac, Yesilipek, Akif, Sedlacek, Petr, Bierings, Marc, Ifversen, Marianne, Sufliarska, Sabina, Kalwak, Krzysztof, Lankester, Arjan, Toporski, Jacek, Di Maio, Lucia, Glogova, Evgenia, Poetschger, Ulrike, and Peters, Christina

Published
2019
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3. Allogeneic Stem Cell Transplantation from HLA-Mismatched Donors for Pediatric Patients with Acute Lymphoblastic Leukemia Treated According to the 2003 BFM and 2007 International BFM Studies: Impact of Disease Risk on Outcomes

Author

Dalle, Jean-Hugues, Balduzzi, Adriana, Bader, Peter, Lankester, Arjan, Yaniv, Isaac, Wachowiak, Jacek, Pieczonka, Anna, Bierings, Marc, Yesilipek, Akif, Sedlaçek, Petr, Ifversen, Marianne, Sufliarska, Sabina, Toporski, Jacek, Glogova, Evgenia, Poetschger, Ulrike, and Peters, Christina

Published
2018
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4. Phase II Study of Sequential Infusion of Donor Lymphocyte Infusion and Cytokine-Induced Killer Cells for Patients Relapsed after Allogeneic Hematopoietic Stem Cell Transplantation

Author

Introna, Martino, Lussana, Federico, Algarotti, Alessandra, Gotti, Elisa, Valgardsdottir, Rut, Micò, Caterina, Grassi, Anna, Pavoni, Chiara, Ferrari, Maria Luisa, Delaini, Federica, Todisco, Elisabetta, Cavattoni, Irene, Deola, Sara, Biagi, Ettore, Balduzzi, Adriana, Rovelli, Attilio, Parma, Matteo, Napolitano, Sara, Sgroi, Giusy, Marrocco, Emanuela, Perseghin, Paolo, Belotti, Daniela, Cabiati, Benedetta, Gaipa, Giuseppe, Golay, Josée, Biondi, Andrea, and Rambaldi, Alessandro

Published
2017
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5. Treatment of Graft versus Host Disease with Mesenchymal Stromal Cells: A Phase I Study on 40 Adult and Pediatric Patients

Author

Introna, Martino, Lucchini, Giovanna, Dander, Erica, Galimberti, Stefania, Rovelli, Attilio, Balduzzi, Adriana, Longoni, Daniela, Pavan, Fabio, Masciocchi, Francesca, Algarotti, Alessandra, Micò, Caterina, Grassi, Anna, Deola, Sara, Cavattoni, Irene, Gaipa, Giuseppe, Belotti, Daniela, Perseghin, Paolo, Parma, Matteo, Pogliani, Enrico, Golay, Josee, Pedrini, Olga, Capelli, Chiara, Cortelazzo, Sergio, D’Amico, Giovanna, Biondi, Andrea, Rambaldi, Alessandro, and Biagi, Ettore

Published
2014
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6. Allogeneic Hematopoietic Stem Cell Transplantation for Philadelphia-Positive Acute Lymphoblastic Leukemia in Children and Adolescents: A Retrospective Multicenter Study of the Italian Association of Pediatric Hematology and Oncology (AIEOP)

Author

Fagioli, Franca, Zecca, Marco, Rognoni, Carla, Lanino, Edoardo, Balduzzi, Adriana, Berger, Massimo, Messina, Chiara, Favre, Claudio, Rabusin, Marco, Lo Nigro, Luca, Masetti, Riccardo, Prete, Arcangelo, and Locatelli, Franco

Published
2012
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7. Platelet-lysate-Expanded Mesenchymal Stromal Cells as a Salvage Therapy for Severe Resistant Graft-versus-Host Disease in a Pediatric Population

Author

Lucchini, Giovanna, Introna, Martino, Dander, Erica, Rovelli, Attilio, Balduzzi, Adriana, Bonanomi, Sonia, Salvadè, Agnese, Capelli, Chiara, Belotti, Daniela, Gaipa, Giuseppe, Perseghin, Paolo, Vinci, Paola, Lanino, Edoardo, Chiusolo, Patrizia, Orofino, Maria Grazia, Marktel, Sarah, Golay, Jose, Rambaldi, Alessandro, Biondi, Andrea, D'Amico, Giovanna, and Biagi, Ettore

Published
2010
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8. Early (Day −7) versus Conventional (Day −1) Inception of Cyclosporine-A for Graft-versus-Host Disease Prophylaxis after Unrelated Donor Hematopoietic Stem Cell Transplantation in Children. Long-Term Results of an AIEOP Prospective, Randomized Study

Author

Lanino, Edoardo, Rondelli, Roberto, Locatelli, Franco, Messina, Chiara, Pession, Andrea, Balduzzi, Adriana, Favre, Claudio, Santarone, Stella, Rabusin, Marco, Pollichieni, Simona, Cesaro, Simone, and Dini, Giorgio

Published
2009
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9. The Value of Minimal Residual Disease (and Diamonds)

Author

Adriana Balduzzi and Balduzzi, A

Subjects
Neoplasm, Residual, Mineralogy, Acute lymphoblastic leukemia, Residual, Chimerism, Precursor Cell Lymphoblastic Leukemia Lymphoma, 03 medical and health sciences, 0302 clinical medicine, Neoplasm Recurrence, Humans, Transplantation, Homologous, Medicine, Relapse, Transplantation, Homologou, Pediatric, Transplantation Chimera, Transplantation, business.industry, Minimal residual disease, Hematopoietic Stem Cell Transplantation, Hematology, Precursor Cell Lymphoblastic Leukemia-Lymphoma, 030220 oncology & carcinogenesis, Neoplasm Recurrence, Local, Diamond, business, Value (mathematics), Human, 030215 immunology
Published
2017

10. Treatment of Graft versus Host Disease with Mesenchymal Stromal Cells: A Phase I Study on 40 Adult and Pediatric Patients

Author

Francesca Masciocchi, Attilio Rovelli, Giovanna D'Amico, Sergio Cortelazzo, Adriana Balduzzi, Anna Grassi, Ettore Biagi, Martino Introna, Olga Pedrini, Giovanna Lucchini, Paolo Perseghin, Andrea Biondi, Giuseppe Gaipa, Daniela Longoni, Chiara Capelli, Stefania Galimberti, Erica Dander, Enrico Maria Pogliani, Fabio Pavan, Irene Cavattoni, Matteo Parma, Sara Deola, Josée Golay, Alessandra Algarotti, Daniela Belotti, Caterina Micò, Alessandro Rambaldi, Introna, M, Lucchini, G, Dander, E, Galimberti, S, Rovelli, A, Balduzzi, A, Longoni, D, Pavan, F, Masciocchi, F, Algarotti, A, Micò, C, Grassi, A, Deola, S, Cavattoni, I, Gaipa, G, Belotti, D, Perseghin, P, Parma, M, Pogliani, E, Golay, J, Pedrini, O, Capelli, C, Cortelazzo, S, D'Amico, G, Biondi, A, Rambaldi, A, and Biagi, E

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Mesenchymal stromal cells, Graft vs Host Disease, Antineoplastic Agents, Disease, Mesenchymal Stem Cell Transplantation, Severity of Illness Index, Gastroenterology, Steroid refractory graft-versus-host disease (GVHD), Cell therapy, Internal medicine, medicine, Humans, Transplantation, Homologous, Child, Adverse effect, Aged, Transplantation, Mesenchymal stromal cell, business.industry, Remission Induction, Mesenchymal stem cell, Infant, Immunosuppression, Hematology, Middle Aged, medicine.disease, Survival Analysis, Acute toxicity, Immunosuppressive treatment, Surgery, Graft-versus-host disease, Drug Resistance, Neoplasm, Child, Preschool, Hematologic Neoplasms, Hematopoietic stem cell transplantation (HSCT), Female, Steroids, Platelet lysate, business, Immunosuppressive Agents
Abstract

This phase I multicenter study was aimed at assessing the feasibility and safety of intravenous administration of third party bone marrow–derived mesenchymal stromal cells (MSC) expanded in platelet lysate in 40 patients (15 children and 25 adults), experiencing steroid-resistant grade II to IV graft-versus-host disease (GVHD). Patients received a median of 3 MSC infusions after having failed conventional immunosuppressive therapy. A median cell dose of 1.5 × 106/kg per infusion was administered. No acute toxicity was reported. Overall, 86 adverse events and serious adverse events were reported in the study, most of which (72.1%) were of infectious nature. Overall response rate, measured at 28 days after the last MSC injection, was 67.5%, with 27.5% complete response. The latter was significantly more frequent in patients exhibiting grade II GVHD as compared with higher grades (61.5% versus 11.1%, P = .002) and was borderline significant in children as compared with adults (46.7 versus 16.0%, P = .065). Overall survival at 1 and 2 years from the first MSC administration was 50.0% and 38.6%, with a median survival time of 1.1 years. In conclusion, MSC can be safely administered on top of conventional immunosuppression for steroid resistant GVHD treatment. Eudract Number 2008-007869-23, NCT01764100.

Published
2014

11. Tisagenlecleucel for the Treatment of Pediatric and Young Adult Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia: Updated Analysis of the ELIANA Clinical Trial

Author

Grupp, Stephan A., primary, Maude, Shannon L., additional, Rives, Susana, additional, Baruchel, Andre, additional, Boyer, Michael, additional, Bittencourt, Henrique, additional, Bader, Peter, additional, Buchner, Jochen, additional, Laetsch, Theodore W, additional, Stefanski, Heather, additional, Myers, Gary Douglas, additional, Qayed, Muna, additional, Pulsipher, Michael A., additional, De Moerloose, Barbara, additional, Yanik, Gregory A., additional, Davis, Kara L, additional, Martin, Paul L., additional, Nemecek, Eneida R., additional, Peters, Christina, additional, Krueger, Joerg, additional, Balduzzi, Adriana, additional, Boissel, Nicolas, additional, Mechinaud, Francoise, additional, Leung, Mimi, additional, Eldjerou, Lamis, additional, Bleickardt, Eric, additional, Mueller, Karen Thudium, additional, and Hiramatsu, Hidefumi, additional

Published
2019
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12. Outcome of Children Developing Grade III-IV Acute Graft-Versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation

Author

Bertaina, Alice, primary, Locatelli, Franco, additional, Galimard, Jacques-Emmanuel, additional, Lawitschka, Anita, additional, Balduzzi, Adriana, additional, Dalle, Jean-Hugues, additional, Sedlacek, Petr, additional, Willasch, Andre, additional, Yaniv, Isaac, additional, Labopin, Myriam, additional, Peters, Christina, additional, and Bader, Peter, additional

Published
2019
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14. Platelet-lysate-Expanded Mesenchymal Stromal Cells as a Salvage Therapy for Severe Resistant Graft-versus-Host Disease in a Pediatric Population

Author

Giovanna D'Amico, Maria Grazia Orofino, J. Golay, Daniela Belotti, Ettore Biagi, Martino Introna, Giuseppe Gaipa, Paolo Perseghin, Attilio Rovelli, Andrea Biondi, Giovanna Lucchini, Sonia Bonanomi, Sarah Marktel, Patrizia Chiusolo, Paola Vinci, Edoardo Lanino, Erica Dander, Alessandro Rambaldi, Agnese Salvadè, Chiara Capelli, Adriana Balduzzi, Lucchini, G, Introna, M, Dander, E, Rovelli, A, Balduzzi, A, Bonanomi, S, Salvadè, A, Capelli, C, Belotti, D, Gaipa, G, Perseghin, P, Vinci, P, Lanino, E, Chiusolo, P, Orofino, M, Marktel, S, Golay, J, Rambaldi, A, Biondi, A, D'Amico, G, and Biagi, E

Subjects
Blood Platelets, Compassionate Use Trials, Male, medicine.medical_specialty, Adolescent, Bone marrow transplantation, medicine.medical_treatment, Mesenchymal stromal cells, GVHD, Graft vs Host Disease, Salvage therapy, Mesenchymal Stem Cell Transplantation, Gastroenterology, Cell therapy, immune system diseases, Internal medicine, medicine, Humans, Child, Salvage Therapy, Transplantation, Mesenchymal stromal cell, business.industry, Mesenchymal stem cell, Mesenchymal Stem Cells, Immunosuppression, Hematology, medicine.disease, Surgery, surgical procedures, operative, Graft-versus-host disease, Child, Preschool, Cord blood, Female, Platelet lysate, Stromal Cells, business
Abstract

Despite advances in graft-versus-host-disease (GVHD) treatment, it is estimated that overall survival (OS) at 2 years for hematopoietic cell transplantation (HCT) recipients who experience steroid-resistant GVHD is 10%. Among recent therapeutic approaches for GVHD treatment, mesenchymal stromal cells (MSCs) hold a key position. We describe a multicenter experience of 11 pediatric patients diagnosed with acute or chronic GVHD (aGVHD, cGVHD) treated for compassionate use with GMP-grade unrelated HLA-disparate donors' bone marrow-derived MSCs, expanded in platelet-lysate (PL)-containing medium. Eleven patients (aged 4-15 years) received intravenous (i.v.) MSCs for aGVHD or cGVHD, which was resistant to multiple lines of immunosuppression. The median dose was 1.2 x 10(6)/kg (range: 0.7-3.7 x 10(6)/kg). No acute side effects were observed, and no late side effects were reported at a median follow-up of 8 months (range: 4-18 months). Overall response was obtained in 71.4% of patients, with complete response in 23.8% of cases. None of our patients presented GVHD progression upon MSC administration, but 4 patients presented GVHD recurrence 2 to 5 months after infusion. Two patients developed chronic limited GVHD. This study underlines the safety of PL-expanded MSC use in children. MSC efficacy seems to be greater in aGVHD than in cGVHD, even after failure of multiple lines of immunosuppression.

Published
2010

15. Monitoring of MRD before and after Allogeneic Hematopoietic Cell Transplantation (HCT) of Childhood ALL by FC and RQ-PCR: A Retrospective Assessment on Behalf of the Pdwp of the Ebmt, the Cog, the Pbmtc, the I-Bfm and the Westhafen-Intercontinental-Group

Author

Bader, Peter, primary, Salzmann-Manrique, Emilia, additional, Sr., Adriana Balduzzi, additional, Dalle, Jean-Hugues, additional, Woolfrey, Ann E., additional, Bar, Merav, additional, Verneris, Michael R., additional, Borowitz, Michael J., additional, Shah, Nirali N., additional, Gossai, Nathan, additional, Shaw, Peter John, additional, Chen, Allen R., additional, Kreyenberg, Hermann, additional, Di Maio, Lucia, additional, Eckert, Cornelia, additional, van der Velden, Vincent H.J., additional, Lankester, Arjan, additional, Klingebiel, Thomas E., additional, Peters, Christina, additional, Grupp, Stephan A., additional, and Pulsipher, Michael A., additional

Published
2017
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16. Safe and Effective Treatment of Graft Versus Host Disease with Platelet Lysate-Expanded Mesenchymal Stromal Cells: A Prospective, Multicentric, Phase 1 Study

Author

Ettore Biagi, Giovanna D`Amico, Giovanna Lucchini, Enrico Pogliani, Andrea Biondi, Attilio Rovelli, Paolo Perseghin, Anna Grassi, Fabio Pavan, Adriana Balduzzi, Erica Dander, Alessandro Rambaldi, Maria Caterina Mico, Alessandra Algarotti, Giuseppe Gaipa, Daniela Belotti, Sara Cortellazzo, Matteo Parma, Sara Deola, Francesca Masciocchi, Chiara Capelli, J. Golay, Martino Introna, and Daniela Longoni

Subjects
Pathology, medicine.medical_specialty, Transplantation, Graft-versus-host disease, business.industry, Mesenchymal stem cell, Medicine, Effective treatment, Platelet lysate, Hematology, business, medicine.disease
Published
2013
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17. Epstein-Barr Virus-Related Post-Transplant Lymphoproliferative Disorder in Children Treated with Rituximab: The Impact of Viral Load and Non-Lymphoid Tissue Involvement

Author

Simone Cesaro, Petr Hubacek, Jan Styczyński, J Maertens, W.J.F.M. van der Velden, Adriana Balduzzi, Susanne Matthes, K. Kałwak, R de la Cámara, Agnieszka Tomaszewska, Chiara Nozzoli, Koen Theunissen, Maura Faraci, Franca Fagioli, H. Einsele, Miguel Angel Diaz, Maddalena Migliavacca, Rodrigo Martino, J.P. Donnelly, Jennifer Hoek, Per Ljungman, Hamdy Omar, Lidia Gil, and Simona Sica

Subjects
Transplantation, business.industry, Hematology, medicine.disease_cause, medicine.disease, Epstein–Barr virus, Virology, Post-transplant lymphoproliferative disorder, Lymphatic system, Immunology, medicine, Rituximab, business, Viral load, medicine.drug
Published
2012
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18. 4 - Monitoring of MRD before and after Allogeneic Hematopoietic Cell Transplantation (HCT) of Childhood ALL by FC and RQ-PCR: A Retrospective Assessment on Behalf of the Pdwp of the Ebmt, the Cog, the Pbmtc, the I-Bfm and the Westhafen-Intercontinental-Group

Author

Bader, Peter, Salzmann-Manrique, Emilia, Sr., Adriana Balduzzi, Dalle, Jean-Hugues, Woolfrey, Ann E., Bar, Merav, Verneris, Michael R., Borowitz, Michael J., Shah, Nirali N., Gossai, Nathan, Shaw, Peter John, Chen, Allen R., Kreyenberg, Hermann, Di Maio, Lucia, Eckert, Cornelia, van der Velden, Vincent H.J., Lankester, Arjan, Klingebiel, Thomas E., Peters, Christina, Grupp, Stephan A., and Pulsipher, Michael A.

Published
2017
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19. Immunomonitoring of Transplanted Patients Infused With Mesenchymal Stromal Cells (MSC) for Treating Steroid-Refractory GVHD

Author

Martino Introna, Chiara Capelli, J. Golay, F. Masciocchi, Ettore Biagi, Giuseppe Gaipa, Sonia Bonanomi, Giovanna D'Amico, Paola Vinci, Andrea Biondi, Paolo Perseghin, Erica Dander, Attilio Rovelli, Alessandra Algarotti, Adriana Balduzzi, Alessandro Rambaldi, and Giovanna Lucchini

Subjects
Transplantation, business.industry, Mesenchymal stem cell, Cancer research, Medicine, Hematology, Steroid refractory, business
Published
2011

20. Safe and Effective Treatment of Graft Versus Host Disease with Platelet Lysate-Expanded Mesenchymal Stromal Cells: A Prospective, Multicentric, Phase 1 Study

Author

Lucchini, Giovanna, primary, Introna, Martino, additional, Dander, Erica, additional, Rovelli, Attilio, additional, Balduzzi, Adriana, additional, Longoni, Daniela Valentina, additional, Pavan, Fabio, additional, Masciocchi, Francesca, additional, Algarotti, Alessandra, additional, Mico, Maria Caterina, additional, Grassi, Anna, additional, Deola, Sara, additional, Gaipa, Giuseppe, additional, Belotti, Daniela, additional, Perseghin, Paolo, additional, Parma, Matteo, additional, Pogliani, Enrico, additional, Golay, Jose, additional, Capelli, Chiara, additional, Cortellazzo, Sara, additional, D`Amico, Giovanna, additional, Biondi, Andrea, additional, Rambaldi, Alessandro, additional, and Biagi, Ettore, additional

Published
2013
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21. Epstein-Barr Virus-Related Post-Transplant Lymphoproliferative Disorder in Children Treated with Rituximab: The Impact of Viral Load and Non-Lymphoid Tissue Involvement

Author

Styczynski, J., primary, Gil, L., additional, Ljungman, P., additional, Donnelly, J.P., additional, Martino, R., additional, Theunissen, K., additional, Maertens, J., additional, Kalwak, K., additional, Hubacek, P., additional, Sica, S., additional, van der Velden, W., additional, Omar, H., additional, Nozzoli, C., additional, Fagioli, F., additional, Matthes, S., additional, Diaz, M.A., additional, Migliavacca, M., additional, Balduzzi, A., additional, Faraci, M., additional, Tomaszewska, A., additional, de la Camara, R., additional, Hoek, J., additional, Einsele, H., additional, and Cesaro, S., additional

Published
2012
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22. Immunomonitoring of Transplanted Patients Infused With Mesenchymal Stromal Cells (MSC) for Treating Steroid-Refractory GVHD

Author

Dander, E., primary, Lucchini, G., additional, Vinci, P., additional, Introna, M., additional, Bonanomi, S., additional, Balduzzi, A., additional, Gaipa, G., additional, Perseghin, P., additional, Masciocchi, F., additional, Capelli, C., additional, Golay, J., additional, Algarotti, A., additional, Rambaldi, A., additional, Rovelli, A., additional, Biondi, A., additional, Biagi, E., additional, and D'Amico, G., additional

Published
2011
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