1. Antioxidant and anti-inflammatory activities of the methanolic extract of Neorhodomela aculeate in hippocampal and microglial cells
- Author
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Jung-Soo Han, Da-Qing Jin, Ji Hee Lee, Jin-Young Sung, Han Gil Choi, Chol Seung Lim, and Ilho Ha
- Subjects
Antioxidant ,Cell Survival ,medicine.medical_treatment ,Pharmaceutical Science ,Biology ,medicine.disease_cause ,Nitric Oxide ,Hippocampus ,Antioxidants ,Nitric oxide ,Cell Line ,Lipid peroxidation ,chemistry.chemical_compound ,Mice ,Picrates ,medicine ,Animals ,Pharmacology ,chemistry.chemical_classification ,Reactive oxygen species ,Methanol ,Anti-Inflammatory Agents, Non-Steroidal ,Biphenyl Compounds ,Neurotoxicity ,General Medicine ,Hydrogen Peroxide ,medicine.disease ,Rats ,Biphenyl compound ,Nitric oxide synthase ,Neuroprotective Agents ,chemistry ,Biochemistry ,Rhodophyta ,biology.protein ,Lipid Peroxidation ,Microglia ,Reactive Oxygen Species ,Oxidative stress - Abstract
The antioxidant and anti-inflammatory properties of the marine red alga Neorhodomela aculeate (N. aculeata) Masuda were investigated with neuronal and microglial cells. Extracts of N. aculeata had potent neuroprotective effects on glutamate-induced neurotoxicity and inhibited reactive oxygen species (ROS) generation in the murine hippocampal HT22 cell line. Also, extracts of N. aculeata inhibited H2O2-induced lipid peroxidation in rat brain homogenates. The properties of the extract as an anti-inflammatory agent were investigated in microglial activation by interferon-gamma (IFN-gamma): it reduced the inducible nitric oxide synthase that consequently resulted in the reduction of nitric oxide. These results suggest that the marine red alga N. aculeata could be considered as a potential source for reducing reactive oxygen species and inflammation related to neurological diseases. more...
- Published
- 2006