1. Effect of dietary fluoride on selenite toxicity in the rat
- Author
-
Qing Yu, Philip D. Whanger, Florian L. Cerklewski, Olaf R. Hedstrom, and James W. Ridlington
- Subjects
Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,chemistry.chemical_element ,Kidney ,Biochemistry ,Inorganic Chemistry ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Eating ,Fluorides ,Selenium ,Internal medicine ,medicine ,Animals ,Xanthine oxidase ,Whole blood ,chemistry.chemical_classification ,Glutathione Peroxidase ,Glutathione peroxidase ,Liver Diseases ,Biochemistry (medical) ,General Medicine ,Glutathione ,Diet ,Rats ,Endocrinology ,medicine.anatomical_structure ,chemistry ,Liver ,Toxicity ,Chemical and Drug Induced Liver Injury ,Fluoride - Abstract
Three factorial experiments were conducted to determine if high dietary fluoride (F) would inhibit selenite toxicity in rats. Initially, three levels of selenite (0.05, 3, and 5 mg/kg diet) were matched against three levels of F (2, 75, and 150 mg/kg diet). Fluoride failed to prevent the depressive effect of selenite on 8-wk food intake and body wt gain. Selenium (Se) concentration of plasma and kidney and enzymatic activity of whole blood glutathione peroxidase (GSH-Px) were also unaffected by F. Liver Se concentration, however, was slightly (12%) but significantly (p
- Published
- 1992