1. Trace Element Determination and Cardioprotection of Terminalia pallida Fruit Ethanolic Extract in Isoproterenol Induced Myocardial Infarcted Rats by ICP-MS.
- Author
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Althaf Hussain S, Kareem MA, Rasool SN, Al Omar SY, Saleh A, Al-Fwuaires MA, Daddam JR, and Devi KL
- Subjects
- Animals, Ethanol chemistry, Isoproterenol antagonists & inhibitors, Male, Minerals administration & dosage, Minerals analysis, Minerals pharmacology, Myocardial Infarction chemically induced, Plant Extracts administration & dosage, Plant Extracts chemistry, Rats, Rats, Wistar, Trace Elements administration & dosage, Trace Elements analysis, Fruit chemistry, Myocardial Infarction prevention & control, Plant Extracts pharmacology, Terminalia chemistry, Trace Elements pharmacology
- Abstract
The trace elements and minerals in Terminalia pallida fruit ethanolic extract (TpFE) were determined by the instrument inductively coupled plasma-mass spectrometry (ICP-MS), and the cardioprotection of TpFE against isoproterenol (ISO)-administered rats was studied. Rats were pretreated with TpFE (100, 300, and 500 mg/kg bw) for 30 days, with concurrent administration of ISO (85 mg/kg bw) for two consecutive days. The levels of trace elements and minerals in TpFE were below the permitted limits of World Health Organization standards. ISO administration significantly increased the heart weight and cardiac marker enzymes in serum, xanthine oxidase, sodium, and calcium in the heart, whereas significantly decreased body weight, reduced glutathione, glutathione-S-transferase, superoxide dismutase, and potassium in the heart. Oral pretreatment of TpFE significantly prevented the ISO-induced alterations. This is the first report that revealed the determination of trace elements and mineral nutrients of TpFE by ICP-MS which plays a principal role in the herbal drug discovery for the treatment of cardiovascular diseases.
- Published
- 2018
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