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Background The development of adaptive implicit and explicit emotion regulation skills is crucial for mental health. Adolescence and emerging adulthood are periods of heightened risk for psychopathology associated with emotion dysregulation, and neurodevelopmental mechanisms have been proposed to account for this increased risk. However, progress in understanding these mechanisms has been hampered by an incomplete knowledge of the neural underpinnings of emotion regulation during development. Methods Using activation likelihood estimation, we conducted a quantitative analysis of functional magnetic resonance imaging studies in healthy developmental samples (i.e., adolescence [10–18 years of age] and emerging adulthood [19–30 years of age]) investigating emotion reactivity (N studies = 48), and implicit (N studies = 41) and explicit (N studies = 19) emotion regulation processes. Results Explicit emotion regulation was associated with activation in frontal, temporal, and parietal regions, whereas both implicit regulation and emotion reactivity were associated with activation in the amygdala and posterior temporal regions. During implicit regulation, adolescents exhibited more consistent activation of the amygdala, fusiform gyrus, and thalamus than emerging adults, who showed more consistent activation in the posterior superior temporal sulcus. Conclusions Our results suggest that emotion reactivity and regulation in developmental samples engage a robust group of regions that are implicated in bottom-up and top-down emotional responding. Adolescents are also more likely to recruit regions involved in early stages of emotion processing during implicit regulation, while emerging adults recruit higher-order regions involved in the extraction of semantic meaning. Findings have implications for future research aiming to better understand the neurodevelopmental mechanisms underlying risk for psychopathology.

Background There is growing evidence that long-term, heavy cannabis use is associated with alterations in regional brain volumes. Although these changes are frequently attributed to the neurotoxic effects of cannabis, it is possible that some abnormalities might predate use and represent markers of vulnerability. To date, no studies have examined whether structural brain abnormalities are present before the onset of cannabis use. This study aims to determine whether adolescents who have initiated cannabis use early (i.e., before age 17 years) show premorbid structural abnormalities in the amygdala, hippocampus, orbitofrontal cortex, and anterior cingulate cortex. Methods Participants ( n = 121) were recruited from primary schools in Melbourne, Australia, as part of a larger study examining adolescent emotional development. Participants underwent structural magnetic resonance imaging at age 12 years and were assessed for cannabis use 4 years later, at age 16 years. At the follow-up assessment, 28 participants had commenced using cannabis (16 female subjects [57%]), and 93 had not (43 female subjects [46%]). Results Smaller orbitofrontal cortex volumes at age 12 years predicted initiation of cannabis use by age 16 years. The volumes of other regions (amygdala, hippocampus, and anterior cingulate cortex) did not predict later cannabis use. Conclusions These findings suggest that structural abnormalities in the orbitofrontal cortex might contribute to risk for cannabis exposure. Although the results have important implications for understanding neurobiological predictors of cannabis use, further research is needed to understand their relationship with heavier patterns of use in adulthood as well as later abuse of other substances.