1. A Comprehensive Analysis of Nuclear-Encoded Mitochondrial Genes in Schizophrenia
- Author
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Carolina Cappi, Patrick F. Sullivan, Jonas Bybjerg-Grauholm, James L. Kennedy, Marquis P. Vawter, Christian M. Hagen, Ari B. Cuperfain, Clement C. Zai, Andriy Derkach, Vanessa F. Gonçalves, Lei Sun, Adolfo Sequeira, Michael Christiansen, Jennie G. Pouget, and Paula L. Hedley
- Subjects
Adult ,Male ,0301 basic medicine ,Stratified FDR ,Mitochondrial DNA ,GWAS-HD ,Adolescent ,Genomics ,Oxidative phosphorylation ,Mitochondrion ,Biology ,Article ,Young Adult ,03 medical and health sciences ,MAGMA ,Humans ,Genetic Predisposition to Disease ,Genetic risk ,Gene-gene interaction ,Gene ,Biological Psychiatry ,Aged ,Genetic association ,Genetics ,Middle Aged ,Control subjects ,Mitochondria ,Genes, Mitochondrial ,030104 developmental biology ,Schizophrenia ,Female ,Genome-Wide Association Study - Abstract
BACKGROUND: The genetic risk factors of schizophrenia (SCZ), a severe psychiatric disorder, are not yet fully understood. Multiple lines of evidence suggest mitochondrial dysfunction may play a role in SCZ, but comprehensive association studies are lacking. We hypothesized that variants in nuclear-encoded mitochondrial genes influence susceptibility to SCZ. METHODS: We conducted gene-based and gene-set analyses using summary association results from the Schizophrenia Psychiatric Genomics Consortium GWAS (PGC-SCZ2) comprising 35,476 cases and 46,839 controls. We applied the MAGMA method to three sets of nuclear-encoded mitochondrial genes: oxidative phosphorylation genes, other nuclear-encoded mitochondrial genes, and genes involved in nucleus-mitochondria crosstalk. Furthermore, we conducted a replication study using the iPSYCH SCZ sample of 2,290 cases and 21,621 controls. RESULTS: In the PGC-SCZ2 sample, 1,186 mitochondrial genes were analyzed among which 159 had p-values
- Published
- 2018
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