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Start Over Author "Nibuya M" Journal biological psychiatry
3 results on '"Nibuya M"'

3. Plasma homovanillic acid, plasma anti-D1 and -D2 dopamine-receptor activity, and negative symptoms in chronically mediated schizophrenia.

Author

Suzuki E, Kanba S, Nibuya M, Koshikawa H, Nakaki T, and Yagi G

Subjects
Brain drug effects, Dose-Response Relationship, Drug, Female, Hospitalization, Humans, Male, Middle Aged, Receptors, Dopamine D1, Receptors, Dopamine D2, Schizophrenia blood, Antipsychotic Agents therapeutic use, Psychiatric Status Rating Scales, Receptors, Dopamine drug effects, Schizophrenia drug therapy, Schizophrenic Psychology
Abstract

We have investigated the relationship between the concentration of homovanillic acid in human plasma (pHVA) and plasma anti-D1 and anti-D2 dopamine receptor activity in chronic schizophrenic patients whose neuroleptic dosage was changed. The change in pHVA level correlated with that in anti-D1, not anti-D2 activity, thus suggesting that the neuroleptic-induced changes in pHVA concentration may be associated with the blocking of D1- as well as D2- receptors. The change of scores on the Scale for the Assessment of Negative Symptoms did not significantly correlate with changes in anti-D1 or anti-D2 activity, but did so correlated with the change in pHVA level.

Published
1992
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