1. Smaller Hippocampal Volume in Posttraumatic Stress Disorder
- Author
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Chadi G. Abdallah, Richard A. Bryant, Regina E. McGlinchey, Jessie L. Frijling, Mirjam van Zuiden, Rajendra A. Morey, John H. Krystal, William P. Milberg, Jonathan C Ipser, Anthony P. King, Laura Nawijn, Elbert Geuze, Neda Jahanshad, Israel Liberzon, Premika S.W. Boedhoe, Margaret A. Sheridan, Sanne J.H. van Rooij, Ilan Harpaz-Rotem, Jim Lagopoulos, Paul M. Thompson, Milissa L. Kaufman, Lauren A.M. Lebois, Max R. Bennett, Sherry Winternitz, David H. Salat, Emily L. Dennis, Jeffrey M. Spielberg, Kerry J. Ressler, Xin Wang, Ruth A. Lanius, Lauren K. O’Connor, Katie A. McLaughlin, Justin T. Baker, Jasmeet P. Hayes, Staci A. Gruber, Ifat Levy, Sarah L. Davis, Maria Densmore, Erika J. Wolf, Mark W. Logue, Dan J. Stein, Saskia B. J. Koch, Kristen M. Wrocklage, Jonathan D. Wolff, Miranda Olff, Dick J. Veltman, Kathleen Thomaes, Mayuresh S. Korgaonkar, Sheri Koopowitz, Mark W. Miller, Tanja Jovanovic, Courtney C. Haswell, Jennifer S. Stevens, Matthew Peverill, Anatomy and neurosciences, Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Brain Imaging, APH - Personalized Medicine, APH - Global Health, ANS - Brain Imaging, Other departments, Adult Psychiatry, and Graduate School
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Adult ,Male ,Thalamus ,Neuroimaging ,Nucleus accumbens ,Hippocampal formation ,Amygdala ,Hippocampus ,Article ,Childhood trauma ,Cohort Studies ,Stress Disorders, Post-Traumatic ,03 medical and health sciences ,Lateral ventricles ,0302 clinical medicine ,Meta-Analysis as Topic ,Lateral Ventricles ,mental disorders ,Medicine ,Humans ,Gender differences ,Biological Psychiatry ,Sex Characteristics ,business.industry ,Putamen ,PTSD ,Magnetic Resonance Imaging ,Corpus Striatum ,030227 psychiatry ,3. Good health ,Structural MRI ,medicine.anatomical_structure ,Adult Survivors of Child Adverse Events ,Female ,Biological psychiatry ,business ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Background Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)–Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group. Methods We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date. We assessed the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle). We used a standardized image-analysis and quality-control pipeline established by the ENIGMA consortium. Results In a meta-analysis of all samples, we found significantly smaller hippocampi in subjects with current PTSD compared with trauma-exposed control subjects (Cohen’s d = −0.17, p = .00054), and smaller amygdalae (d = −0.11, p = .025), although the amygdala finding did not survive a significance level that was Bonferroni corrected for multiple subcortical region comparisons (p Conclusions Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain’s response to trauma.
- Published
- 2018
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