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Your search keyword '"Lardner, Casey K."' showing total 6 results
Start Over Author "Lardner, Casey K." Language english Journal biological psychiatry
6 results on '"Lardner, Casey K."'

2. Crystallin Mu in Medial Amygdala Mediates the Effect of Social Experience on Cocaine Seeking in Males but Not in Females

Author

Walker, Deena M., Zhou, Xianxiao, Cunningham, Ashley M., Ramakrishnan, Aarthi, Cates, Hannah M., Lardner, Casey K., Peña, Catherine J., Bagot, Rosemary C., Issler, Orna, Van der Zee, Yentl, Lipschultz, Andrew P., Godino, Arthur, Browne, Caleb J., Hodes, Georgia E., Parise, Eric M., Torres-Berrio, Angelica, Kennedy, Pamela J., Shen, Li, Zhang, Bin, and Nestler, Eric J.

Published
2022
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4. Cocaine Self-administration Alters Transcriptome-wide Responses in the Brain’s Reward Circuitry

Author

Walker, Deena M., Cates, Hannah M., Loh, Yong-Hwee E., Purushothaman, Immanuel, Ramakrishnan, Aarthi, Cahill, Kelly M., Lardner, Casey K., Godino, Arthur, Kronman, Hope G., Rabkin, Jacqui, Lorsch, Zachary S., Mews, Philipp, Doyle, Marie A., Feng, Jian, Labonté, Benoit, Koo, Ja Wook, Bagot, Rosemary C., Logan, Ryan W., Seney, Marianne L., Calipari, Erin S., Shen, Li, and Nestler, Eric J.

Published
2018
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6. Sex-Specific Role for SLIT1 in Regulating Stress Susceptibility.

Author

van der Zee, Yentl Y., Lardner, Casey K., Parise, Eric M., Mews, Philipp, Ramakrishnan, Aarthi, Patel, Vishwendra, Teague, Collin D., Salery, Marine, Walker, Deena M., Browne, Caleb J., Labonté, Benoit, Parise, Lyonna F., Kronman, Hope, Penã, Catherine J., Torres-Berrío, Angélica, Duffy, Julia E., de Nijs, Laurence, Eijssen, Lars M.T., Shen, Li, and Rutten, Bart

Subjects
*MENTAL depression, *PYRAMIDAL neurons, *RNA sequencing, *PSYCHOLOGICAL stress, *DEPRESSION in men, *CELLULAR signal transduction, *GENDER differences (Psychology)
Abstract

Major depressive disorder is a pervasive and debilitating syndrome characterized by mood disturbances, anhedonia, and alterations in cognition. While the prevalence of major depressive disorder is twice as high for women as men, little is known about the molecular mechanisms that drive sex differences in depression susceptibility. We discovered that SLIT1, a secreted protein essential for axonal navigation and molecular guidance during development, is downregulated in the adult ventromedial prefrontal cortex (vmPFC) of women with depression compared with healthy control subjects, but not in men with depression. This sex-specific downregulation of Slit1 was also observed in the vmPFC of mice exposed to chronic variable stress. To identify a causal, sex-specific role for SLIT1 in depression-related behavioral abnormalities, we performed knockdown (KD) of Slit1 expression in the vmPFC of male and female mice. When combined with stress exposure, vmPFC Slit1 KD reflected the human condition by inducing a sex-specific increase in anxiety- and depression-related behaviors. Furthermore, we found that vmPFC Slit1 KD decreased the dendritic arborization of vmPFC pyramidal neurons and decreased the excitability of the neurons in female mice, effects not observed in males. RNA sequencing analysis of the vmPFC after Slit1 KD in female mice revealed an augmented transcriptional stress signature. Together, our findings establish a crucial role for SLIT1 in regulating neurophysiological and transcriptional responses to stress within the female vmPFC and provide mechanistic insight into novel signaling pathways and molecular factors influencing sex differences in depression susceptibility. [ABSTRACT FROM AUTHOR]

Published
2022
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