1. MSABrowser: dynamic and fast visualization of sequence alignments, variations and annotations
- Author
-
Halil I. Bilgin, Furkan M. Torun, and Oktay I. Kaplan
- Subjects
Source code ,Information retrieval ,Computer science ,business.industry ,media_common.quotation_subject ,Sequence alignment ,General Medicine ,JavaScript ,Visualization ,Software ,Documentation ,OS X ,Pairwise comparison ,business ,computer ,computer.programming_language ,media_common - Abstract
SummarySequence alignment is an excellent way to visualize the similarities and differences between DNA, RNA, or protein sequences, yet it is currently difficult to jointly view sequence alignment data with genetic variations, modifications such as post-translational modifications, and annotations (i.e. protein domains). Here, we develop the MSABrowser tool that makes it easy to co-visualize genetic variations, modifications, and annotations on the respective positions of amino acids or nucleotides in pairwise or multiple sequence alignments. MSABrowser is developed entirely in JavaScript and works on any modern web browser at any platform, including Linux, Mac OS X, and Windows systems without any installation. MSABrowser is also freely available for the benefit of the scientific community.Availability and implementationMSABrowser is released as open-source and web-based software under GNU General Public License, version 3.0 (GPLv3). The visualizer, documentation, all source codes, and examples are available athttp://thekaplanlab.github.io/and GitHub repositoryhttps://github.com/thekaplanlab/msabrowser.Supplementary informationSupplementary data are available online.
- Published
- 2021
- Full Text
- View/download PDF