1. SpliceAid: a database of experimental RNA target motifs bound by splicing proteins in humans
- Author
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Giovanni Principato, Francesco Piva, Linda Nocchi, and Matteo Giulietti
- Subjects
Statistics and Probability ,Internet ,Binding Sites ,Rna processing ,Database ,Sequence database ,RNA Splicing ,RNA-Binding Proteins ,RNA ,Biology ,computer.software_genre ,Biochemistry ,Computer Science Applications ,Computational Mathematics ,Splicing factor ,ComputingMethodologies_PATTERNRECOGNITION ,Computational Theory and Mathematics ,RNA splicing ,Compact form ,Humans ,Databases, Nucleic Acid ,Molecular Biology ,computer - Abstract
Summary: The correct post-transcriptional RNA processing is finely regulated by RNA-binding proteins. Unfortunately, there is little experimental information on target RNA sequences of RNA-binding proteins and moreover such experimentally derived target sequences are annotated in a compact form by the score matrices that overestimate the number of possible recognized sequences. We carried out an exhaustive hand curated literature search to create a database, SpliceAid, collecting all the experimentally assessed target RNA sequences that are bound by splicing proteins in humans. We built a web resource, database driven, to easy query SpliceAid and give back the results by an accurate and dynamic graphic representation. Availability: SpliceAid database is freely accessible at http://www.introni.it/splicing.html Contact: f.piva@univpm.it
- Published
- 2009
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