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Start Over Author "Chen Zou" Journal bioengineered
4 results on '"Chen Zou"'

2. Long non-coding RNA LINC00472 inhibits oral squamous cell carcinoma via miR-4311/GNG7 axis

Author

Chen, Zou, Xiaozhi, Lv, Haigang, Wei, Siyuan, Wu, Jing, Song, Zhe, Tang, Shiwei, Liu, Xia, Li, and Yilong, Ai

Subjects
Squamous Cell Carcinoma of Head and Neck, Bioengineering, General Medicine, Applied Microbiology and Biotechnology, Gene Expression Regulation, Neoplastic, MicroRNAs, Head and Neck Neoplasms, Cell Line, Tumor, GTP-Binding Protein gamma Subunits, Carcinoma, Squamous Cell, Humans, Mouth Neoplasms, RNA, Long Noncoding, Cell Proliferation, Biotechnology
Abstract

Emerging studies indicate that long non-coding RNAs play important roles in oral squamous cell carcinoma (OSCC). However, the function of the majority of long non-coding RNAs is still unclear. Recently, LINC00472 has been reported to play crucial roles in multiple cancers. However, the role of LINC00472 in oral squamous cell carcinoma (OSCC) is still not clear. This study found that LncRNA LINC00472 was significantly down-regulated in several squamous cell carcinoma cancer tissues and OSCC cell lines. Over-expression of LINC00472 in OSCC cells inhibited OSCC progression and alleviated OSCC immune responses. Additionally, we confirmed that LINC00472 functioned as an hsa-miR-4311 sponge and regulated the expression of GNG7 (guanine nucleotide-binding protein, gamma 7). Also, we found that LINC00472 over-expression could suppress xenograft tumor growth in

Published
2022

3. Circular RNA mitochondrial translation optimization 1 homologue (CircMTO1) induced by zinc finger protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / alpha thalassemia/mental retardation, X-linked (ATRX) axis

Author

Siyuan Wu, Jing Song, Yilong Ai, Xia Li, Hailing Luo, Haigang Wei, Zhe Tang, Xiaozhi Lv, and Chen Zou

Subjects
X-linked Nuclear Protein, RNA, Mitochondrial, Mitochondrial translation, znf460, circular rna, Bioengineering, circmto1, Biology, Applied Microbiology and Biotechnology, Circular RNA, Cell Line, Tumor, microRNA, medicine, Humans, RNA, Neoplasm, ATRX, Zinc finger, Gene knockdown, Squamous Cell Carcinoma of Head and Neck, Cell growth, Cancer, RNA, Circular, mir-320a, General Medicine, medicine.disease, Neoplasm Proteins, DNA-Binding Proteins, oral squamous cell carcinoma, MicroRNAs, stomatognathic diseases, Head and Neck Neoplasms, Cancer research, atrx, TP248.13-248.65, Research Article, Research Paper, Transcription Factors, Biotechnology
Abstract

Oral squamous cell carcinoma (OSCC) is one of the most common cancer types of head and neck cancer, accounting for 95% of all cases. However, the mechanisms underlying the pathogenesis of OSCC remain unclear. Circular RNA (CircRNA) has been extensively studied in the past decades and is a promising direction for the development of OSCC therapeutic targets. In this study, we aimed to investigate the role of circMTO1 in OSCC progression. First, we validated the characterization and expression of circMTO1 in OSCC. It was found that circMTO1 was upregulated in OSCC tumor tissues and cells. Subsequently, we conducted biological experiments. It was found that circMTO1 knockdown inhibited OSCC cell proliferation, migration, and invasion. Furthermore, we conducted a series of experiments to elucidate the underlying mechanisms. A novel circMTO1/miR-320a/ATRX axis was identified. Our results suggest that circMTO1 modulates ATRX expression to accelerate OSCC progression by sponging miR-320a. Moreover, we found that circMTO1 expression in OSCC was transcriptionally regulated by Zinc Finger Protein 460 (ZNF460). Our study showed a novel ZNF460/circMTO1/miR-320a/ATRX signaling in OSCC development.

Published
2021

4. Circular

Author

Chen, Zou, Xia, Li, Haigang, Wei, Siyuan, Wu, Jing, Song, Zhe, Tang, Hailing, Luo, Xiaozhi, Lv, and Yilong, Ai

Subjects
Gene Expression Regulation, Neoplastic, MicroRNAs, Carcinogenesis, Cell Movement, Head and Neck Neoplasms, Squamous Cell Carcinoma of Head and Neck, Cell Line, Tumor, Carcinoma, Squamous Cell, Humans, Membrane Proteins, Mouth Neoplasms, RNA, Circular, 3' Untranslated Regions
Abstract

Circular RNAs, which are a novel subclass of noncoding RNAs, are reported to be involved in various biological processes. Aberrant expression of circular RNAs may promote cancer progression. The function of circular

Published
2022

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