1. Recent progress on the application of
- Author
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Valerie, Booth, Dror E, Warschawski, Nury P, Santisteban, Marwa, Laadhari, and Isabelle, Marcotte
- Subjects
Membrane Lipids ,Bacteria ,Bacterial Proteins ,Cell Membrane ,Membrane Proteins ,Deuterium ,Nuclear Magnetic Resonance, Biomolecular ,Antimicrobial Cationic Peptides - Abstract
Discoveries relating to innate immunity and antimicrobial peptides (AMPs) granted Bruce Beutler and Jules Hoffmann a Nobel prize in medicine in 2011, and opened up new avenues for the development of therapies against infections, and even cancers. The mechanisms by which AMPs interact with, and ultimately disrupt, bacterial cell membranes is still, to a large extent, incompletely understood. Up until recently, this mechanism was studied using model lipid membranes that failed to reproduce the complexity of molecular interactions present in real cells comprising lipids but also membrane proteins, a cell wall containing peptidoglycan or lipopolysaccharides, and other molecules. In this review, we focus on recent attempts to study, at the molecular level, the interaction between cationic AMPs and intact bacteria, by more...
- Published
- 2017