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Start Over Author "Li-Wei Chen" Journal biochemistry research international
2 results on '"Li-Wei Chen"'

1. Long-Term Use of Probiotic-Containing Yogurts Is a Safe Way to Prevent Helicobacter pylori: Based on a Mongolian Gerbil's Model

Author

Chao-Hung Kuo, Sophie S. W. Wang, Chien-Yu Lu, Huang-Ming Hu, Fu-Chen Kuo, Bi-Chuang Weng, Chun-Chieh Wu, Chung-Jung Liu, Pei-Yun Tsai, Tsung-Cheng Lee, Li-Wei Chen, Kuang-Hung Cheng, Lin-Li Chang, and Deng-Chyang Wu

Subjects
Biochemistry, QD415-436
Abstract

Background. The suppression of Helicobacter pylori (H. pylori) decreases H. pylori-related diseases. The probiotics have an inhibitory effect on H. pylori. Aim. We investigated the effects of long-term use of yogurt on H. pylori based on Mongolian gerbils’ model. Materials and Methods. Yogurt (containing a supplement of Lactobacillus acidophilus, Bifidobacterium lactis, etc.) was used. Forty-six gerbils were divided into five groups. All groups were inoculated with H. pylori for 5 to 8 weeks. The yogurt was given as follows: Group (Gr.) A: from 1st to 4th week; Gr. B from 5th to 8th week; Gr. C: from 17th week to sacrifice; Gr. D: from 5th week to sacrifice. Gerbils were sacrificed on the 52nd week. Histology was evaluated according to the Sydney system. Results. The positive rates of H. pylori were 60% (Gr. A), 75% (Gr. B), 67% (Gr. C), 44% (Gr. D), and 100% (Gr. E). Gr. D showed lower inflammatory score. Only Gr. E (60%) had intestinal metaplasia. Gr. D showed higher IL-10 and lower TNF-α expression than Gr. E. Conclusion. Long-term intake of yogurt could decrease H. pylori infection. The long-term use of yogurt would be an alternative strategy to manage H. pylori infection.

Published
2013
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2. Long-Term Use of Probiotic-Containing Yogurts Is a Safe Way to Prevent Helicobacter pylori: Based on a Mongolian Gerbil's Model

Author

Huang-Ming Hu, Kuang-Hung Cheng, Deng-Chyang Wu, Tsung-Cheng Lee, Lin-Li Chang, Bi-Chuang Weng, Chao-Hung Kuo, Chung-Jung Liu, Fu-Chen Kuo, Li-Wei Chen, Chun-Chieh Wu, Pei-Yun Tsai, Sophie S.W. Wang, and Chien-Yu Lu

Subjects
medicine.medical_specialty, Article Subject, Bifidobacterium lactis, Gerbil, Biochemistry, Gastroenterology, law.invention, lcsh:Biochemistry, Probiotic, Lactobacillus acidophilus, law, Internal medicine, medicine, lcsh:QD415-436, Inhibitory effect, biology, Traditional medicine, business.industry, Intestinal metaplasia, food and beverages, Histology, Helicobacter pylori, biology.organism_classification, medicine.disease, business, Research Article
Abstract

Background. The suppression ofHelicobacter pylori(H. pylori) decreasesH. pylori-related diseases. The probiotics have an inhibitory effect onH. pylori.Aim. We investigated the effects of long-term use of yogurt onH. pyloribased on Mongolian gerbils’ model.Materials and Methods. Yogurt (containing a supplement ofLactobacillus acidophilus, Bifidobacterium lactis, etc.) was used. Forty-six gerbils were divided into five groups. All groups were inoculated withH. pylorifor 5 to 8 weeks. The yogurt was given as follows: Group (Gr.) A: from 1st to 4th week; Gr. B from 5th to 8th week; Gr. C: from 17th week to sacrifice; Gr. D: from 5th week to sacrifice. Gerbils were sacrificed on the 52nd week. Histology was evaluated according to the Sydney system.Results. The positive rates ofH. pyloriwere 60% (Gr. A), 75% (Gr. B), 67% (Gr. C), 44% (Gr. D), and 100% (Gr. E). Gr. D showed lower inflammatory score. Only Gr. E (60%) had intestinal metaplasia. Gr. D showed higher IL-10 and lower TNF-αexpression than Gr. E.Conclusion.Long-term intake of yogurt could decreaseH. pyloriinfection. The long-term use of yogurt would be an alternative strategy to manageH. pyloriinfection.

Published
2013
Full Text
View/download PDF

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