1. Apoptosis induced by synthetic compounds containing a 3,4,5-trimethoxyphenyl fragment against lymphoid immature neoplasms
- Author
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Ricardo José Nunes, Iris Mattos Santos-Pirath, Maria Cláudia Santos-Silva, Mariana Franzoni Maioral, Patrícia D. Neuenfeldt, and Laura Otto Walter
- Subjects
Cell Survival ,Lymphoblastic Leukemia ,Antineoplastic Agents ,Apoptosis ,Biology ,Biochemistry ,Malignant transformation ,Structure-Activity Relationship ,03 medical and health sciences ,0302 clinical medicine ,Tumor Cells, Cultured ,Humans ,Cytotoxicity ,Molecular Biology ,Cell Proliferation ,030304 developmental biology ,Progenitor ,0303 health sciences ,Acute leukemia ,Dose-Response Relationship, Drug ,Molecular Structure ,Hydrazones ,Acetophenones ,Cell Biology ,Leukemia, Lymphoid ,Hematological malignancy ,030220 oncology & carcinogenesis ,Cancer research ,Drug Screening Assays, Antitumor - Abstract
T-cell acute lymphoblastic leukemia is an aggressive hematological malignancy originating from the malignant transformation of progenitor T cells at different stages of development. The treatment causes severe adverse effects and is associated with relapses and high morbidity and mortality rates. The present study aimed to evaluate the cytotoxic activity of 28 new compounds containing 3,4,5-trimethoxyphenyl analogues on hematological neoplastic cells lines. Cytotoxicity screening by the MTT method revealed that compound 1d was the most promising. Cell viability of neoplastic cells decreased in a concentration- and time-dependent manner, with compound 1d not causing hemolysis or reducing peripheral blood mononuclear cells viability, suggesting a selective cytotoxicity. We also suggested that compound 1d induced apoptotic-like cell death with mitochondrial involvement in Jurkat cells.
- Published
- 2019
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