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Start Over Author "Ya Jung Lee" Journal biochemistry
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1. Modeling of the endosomolytic activity of HA2-TAT peptides with red blood cells and ghosts

Author

Ya-Jung Lee, Johnson, Gregory, and Pellois, Jean-Philippe

Subjects
Biological transport -- Analysis, Glucosamine -- Chemical properties, Glutamate -- Chemical properties, Protein binding -- Analysis, Biological sciences, Chemistry
Abstract

The binding and membrane leakage activity of a glutamic acid-enriched analogue E5-TAT is assessed with red blood cells and giant unilamellar vesicles as membrane models for endosomes to understand the properties of HA2-TAT peptide-based delivery agent inside endosomes which affect the properties of one another. Based on the results a model is proposed for the endosomolytic activity of the peptide which could be applied for the molecular design of future delivery agents.

Published
2010

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