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Your search keyword '"Samhan-Arias, Alejandro K."' showing total 3 results
Start Over Author "Samhan-Arias, Alejandro K." Journal biochemistry
3 results on '"Samhan-Arias, Alejandro K."'

1. Phosphomimetic substitution of cytochrome c tyrosine 48 decreases respiration and binding to cardiolipin and abolishes ability to trigger downstream caspase activation

Author

Pecina, Petr, Borisenko, Grigory G., Belikova, Natalia A., Tyurina, Yulia Y., Pecinova, Alena, Lee, Icksoo, Samhan-Arias, Alejandro K., Przyklenk, Karin, Kagan, Valerian E., and Huttemann, Maik

Subjects
Cytochrome c -- Chemical properties, Cytochrome c -- Structure, Gene expression -- Analysis, Gene mutations -- Analysis, Phosphorylation -- Analysis, Tyrosine -- Chemical properties, Biological sciences, Chemistry
Abstract

The role of mammalian cytochrome c (Cytc) tyrosine phosphorylation is characterized by the overexpression and purification of a Tyr48Glu mutant Cytc, mimicking the in vivo Tyr48 phosphorylation found in cow liver, along with wild-type and Tyr48Phe variants as controls. The studies have shown that in vivo Tyr48 phosphorylation has served as an antiapoptotic switch and have highlighted the strategic position and role of the conserved Cytc residue Tyr48 in regulating multiple functions of Cytc.

Published
2010

2. Phosphomimetic Substitution of CytochromecTyrosine 48 Decreases Respiration and Binding to Cardiolipin and Abolishes Ability to Trigger Downstream Caspase Activation

Author

Pecina, Petr, primary, Borisenko, Grigory G., additional, Belikova, Natalia A., additional, Tyurina, Yulia Y., additional, Pecinova, Alena, additional, Lee, Icksoo, additional, Samhan-Arias, Alejandro K., additional, Przyklenk, Karin, additional, Kagan, Valerian E., additional, and Hüttemann, Maik, additional

Published
2010
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