1. RNA-p53 interactions in vitro
- Author
-
Riley, Kasandra J.-L., Ramirez-Alvarado, Marina, and Maher, L. James, III
- Subjects
Tumor suppressor genes -- Research ,DNA-ligand interactions -- Research ,DNA binding proteins -- Genetic aspects ,DNA binding proteins -- Chemical properties ,Biological sciences ,Chemistry - Abstract
A study was conducted to explore the specificity and function of interaction between the tumor suppressor protein p53 in the yeast three-hybrid system (Y3H) and RNA. The findings prove that p53 binds RNA with little sequence specificity, RNA binding has the potential to regulate DNA binding, and RNA-p53 interactions could be regulated by acetylation of the p53 C-terminus.
- Published
- 2007